Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity

被引：13

作者：

Corea, G

Iorizzi, M

Lanzotti, V

Cammareri, M

Conicella, C

Laezza, C

Bifulco, M

机构：

[1] Univ Molise, Dipartimento Sci & Tecnol Agroalimentari Ambietal, I-86100 Campobasso, Italy

[2] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[3] CNR IGV, Ist Genet Vegetale, Sez Portici, I-80055 Portici, NA, Italy

[4] Univ Naples Federico 2, CNR, Ist Endocrinol & Oncol Sperimentale, I-80131 Naples, Italy

[5] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 18期

关键词：

Aster sedifolius; Asteraceae; triterpenoid saponins; astersedifolioside; antiproliferative activity;

D O I：

10.1016/j.bmc.2004.06.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[alpha-L-rhamnopyranosyl (I --> 2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-alpha-L-rhamnopyranosyl (I --> 2)-alpha-L-arabinopyranoside] (1), 3-O-[alpha-L-rhamnopyranosyl (1 --> 2)-beta-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (1 --> 4)-O-alpha-L-rhamnopyranosyl (1 --> 2)-alpha(-L-arabinopyranoside] (2) and 3-O-[alpha-L-rhamnopyranosyl (I --> 2)-beta-D-glucopyranosyl (I --> 2)-alpha-D-glucopyranosyl] echinocystic acid 28-[O-beta-D-xylopyranosyl (I 4)-O-alpha-L-rhamnopyranosyl (I --> 2)-alpha-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line. (C) 2004 Published by Elsevier Ltd.

引用

页码：4909 / 4915

页数：7

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