Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

被引：75

作者：

Ashrafizadeh, Milad ^{[1
,2
]}

Zarrabi, Ali ^{[2
]}

Hushmandi, Kiavash ^{[3
]}

Hashemi, Farid ^{[4
]}

Moghadam, Ebrahim Rahmani ^{[5
]}

Raei, Mehdi ^{[6
]}

Kalantari, Mahshad ^{[7
]}

Tavakol, Shima ^{[8
]}

Mohammadinejad, Reza ^{[9
]}

Najafi, Masoud ^{[11
,12
]}

Tay, Franklin R. ^{[10
]}

Makvandi, Pooyan ^{[13
,14
]}

机构：

[1] Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey

[2] Sabanci Univ Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[3] Univ Tehran, Fac Vet Med, Dept Food Hyg & Qual Control, Div Epidemiol & Zoonoses, Tehran 1419963114, Iran

[4] Univ Tehran, Fac Vet Med, Dept Comparat Biosci, Tehran, Iran

[5] Shiraz Univ Med Sci, Sch Med, Dept Anat Sci, Student Res Comm, Shiraz 7134814336, Iran

[6] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran 1435916471, Iran

[7] Azad Univ, Dept Genet, Tehran Med Sci Branch, Tehran 19168931813, Iran

[8] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran 1449614525, Iran

[9] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman 7616911319, Iran

[10] Augusta Univ, Coll Grad Studies, Augusta, GA 30912 USA

[11] Kermanshah Univ Med Sci, Med Technol Res Ctr, Inst Hlth Technol, Sch Paramed Sci, Kermanshah 6715847141, Iran

[12] Kermanshah Univ Med Sci, Sch Paramed Sci, Radiol & Nucl Med Dept, Kermanshah 6715847141, Iran

[13] Ist Italiano Tecnol, Ctr MicroBioRobot, I-56025 Pisa, Italy

[14] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran 1449614535, Iran

来源：

ACS COMBINATORIAL SCIENCE | 2020年 / 22卷 / 12期

基金：

英国科研创新办公室;

关键词：

anticancer therapy; chemotherapy; co-delivery platforms; nanocarriers; natural products; small interfering RNA; LOW-DENSITY-LIPOPROTEIN; MESOPOROUS SILICA NANOPARTICLES; CHITOSAN-BASED NANOPARTICLES; EPITHELIAL-MESENCHYMAL TRANSITION; ENHANCED ANTICANCER EFFICACY; MODIFIED CATIONIC LIPOSOMES; SOLID LIPID NANOPARTICLES; CELL-CYCLE REDISTRIBUTION; ANTI-SURVIVIN SIRNA; NANO-GRAPHENE OXIDE;

D O I：

10.1021/acscombsci.0c00099

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, codelivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.

引用

页码：669 / 700

页数：32

共 411 条

[1] Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer
Abd Wahab, Nurul Azwa
Lajis, Nordin H.
Abas, Faridah
Othman, Iekhsan
Naidu, Rakesh
[J]. NUTRIENTS, 2020, 12 (03)
[2] PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy
Abedi-Gaballu, Fereydoon
Dehghan, Gholamreza
Ghaffari, Maryam
Yekta, Reza
Abbaspour-Ravasjani, Soheil
Baradaran, Behzad
Dolatabadi, Jafar Ezzati Nazhad
Hamblin, Michael R.
[J]. APPLIED MATERIALS TODAY, 2018, 12 : 177 - 190
[3] Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer
Abotaleb, Mariam
Liskova, Alena
Kubatka, Peter
Busselberg, Dietrich
[J]. BIOMOLECULES, 2020, 10 (02)
[4] siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?
Acharya, Rituparna
Saha, Suman
Ray, Sayantan
Hazra, Sugata
Mitra, Manoj K.
Chakraborty, Jui
[J]. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 76 : 1378 - 1400
[5] Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel
Akyuva, Yener
Naziroglu, Mustafa
[J]. SCIENTIFIC REPORTS, 2020, 10 (01)
[6] Targeted cancer treatment using a combination of siRNA-liposomes and resveratrol-electrospun fibers in co-cultures
Al-Attar, Thikrayat
Madihally, Sundararajan, V
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 569
[7] Influence of controlled release of resveratrol from electrospun fibers in combination with siRNA on leukemia cells
Al-Attar, Thikrayat
Madihally, Sundararajan, V
[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 123 : 173 - 183
[8] Click modified amphiphilic graft copolymeric micelles of poly(styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk-1 siRNA in cancer therapy
Alex, M. R. Aji
Veeranarayanan, Srivani
Poulose, Aby Cheruvathoor
Nehate, Chetan
Kumar, D. Sakthi
Koul, Veena
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (45) : 7303 - 7313
[9] Design and encapsulation of anticancer dual HSP27 and HER2 inhibitor into low density lipoprotein to target ovarian cancer cells
Alhadad, Laila J.
Harisa, Gamaleldin, I
Alanazi, Fars K.
[J]. SAUDI PHARMACEUTICAL JOURNAL, 2020, 28 (04) : 387 - 396
[10] Understanding co-loading of doxorubicin and camptothecin on graphene and folic acid-conjugated graphene for targeting drug delivery: classical MD simulation and DFT calculation
Alinejad, Abutaleb
Raissi, Heidar
Hashemzadeh, Hassan
[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (09) : 2737 - 2745

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