A peptide from the submandibular glands modulates inflammatory responses

Background: The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified. Results: SGP-T reduced shock-induced hypotension and allergen-induced disruption of migrating myoelectric complexes and the magnitude of smooth muscle contraction. The heptapeptide inhibited the influx of neutrophils into carrageenin-soaked sponges. Conclusion: SGP-T has several biological activities that collectively help explain the ability of the CST-SMG axis to regulate inflammation.