A peptide from the submandibular glands modulates inflammatory responses

被引：3
|
作者：
Mathison, RD
Davison, JS
Befus, AD
机构：
[1] UNIV ALBERTA,FAC MED,PULM RES GRP,EDMONTON,AB TG6 2S2,CANADA
[2] UNIV CALGARY,FAC MED,DEPT PHYSIOL & BIOPHYS,CALGARY,AB,CANADA
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1997年 / 113卷 / 1-3期
关键词：
rat; salivary glands; anaphylaxis; endotoxic shock; neutrophils; neuroimmunology;
D O I：
10.1159/000237594
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Background: The cervical sympathetic trunk-submandibular gland (CST-SMG) axis plays an important role in inflammation. An immunoregulatory heptapeptide, submandibular gland peptide T (SGP-T), was isolated from submandibular glands, and several of its biological activities have been identified. Results: SGP-T reduced shock-induced hypotension and allergen-induced disruption of migrating myoelectric complexes and the magnitude of smooth muscle contraction. The heptapeptide inhibited the influx of neutrophils into carrageenin-soaked sponges. Conclusion: SGP-T has several biological activities that collectively help explain the ability of the CST-SMG axis to regulate inflammation.
引用
收藏
页码：337 / 338
页数：2
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