Two New Naphthalene Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis sp.

被引：8

作者：

Li, Xue-Mei ^{[1
]}

Zeng, Yi-Cheng ^{[1
]}

Chen, Jian-Hua ^{[1
]}

Yang, Ye-Kun ^{[1
]}

Li, Jing ^{[1
]}

Ye, Lin ^{[1
]}

Du, Gang ^{[2
]}

Zhou, Min ^{[2
]}

Hu, Qiu-Fen ^{[2
]}

Guangyu-Yang ^{[1
]}

Yang, Hai-Ying ^{[2
]}

Duan, Yan-Qing ^{[1
]}

机构：

[1] China Tobacco Yunnan Ind Co Ltd, Kunming 650231, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, Kunming 650031, Yunnan, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 04期

基金：

中国国家自然科学基金;

关键词：

naphthalene derivatives; endophytic fungus Phomopsis sp; anti-MRSA activity; XANTHONE DERIVATIVES; ROOTS;

D O I：

10.1007/s10600-019-02762-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new naphthalene derivatives, 5-methoxy-2-methyl-7-(3-methyl-2-oxobut-3-enyl)-1-naphthaldehyde (1) and 2-(hydroxymethyl)-5-methoxy-7-(3-methyl-2-oxobut-3-enyl)-1-naphthaldehyde (2), together with two known naphthalene derivatives (3 and 4), were isolated from the fermentation products of an endophytic fungus Phomopsis sp. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1 and 2 showed good inhibition with IZD of 14.5 +/- 1.2 and 15.2 +/- 1.3 mm, respectively.

引用

页码：618 / 621

页数：4

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