New preaustinoids from a marine-derived fungal strain Penicillium sp. SF-5497 and their inhibitory effects against PTP1B activity

被引：16

作者：

Park, Jin-Soo ^{[1
]}

Tran Hong Quang ^{[2
]}

Nguyen Thi Thanh Ngan ^{[3
]}

Sohn, Jae Hak ^{[4
]}

Oh, Hyuncheol ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 54538, South Korea

[2] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] VAST, Inst Genome Res, 18 Hoang Quoc Viet, Hanoi, Vietnam

[4] Silla Univ, Coll Med & Life Sci, Busan 46958, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 08期

关键词：

INSULIN SENSITIVITY; MEROTERPENES; PROTEIN; ASSOCIATION; DERIVATIVES; OBESITY;

D O I：

10.1038/s41429-019-0187-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemical investigation of the marine-derived fungal isolate Penicillium sp. SF-5497 resulted in the isolation of two new preaustinoid-related meroterpenoids, named preaustinoid A6 (1) and preaustinoid A7 (2), along with three known metabolites (3-5). Their structures were elucidated by extensive spectroscopic analyses, such as 1D and 2D NMR and MS data. Among these, compounds 1 and 3 inhibited PTP1B activity in a dose-dependent manner, with IC50 values of 17.6 and 58.4 mu M, respectively. Furthermore, kinetic analyses indicated that compound 1 inhibited PTP1B in a noncompetitive manner, with the K-i value of 17.0 mu M.

引用

页码：629 / 633

页数：5