Platinum Group Metal Compounds in Cancer Chemotherapy An overview of the history and the potential of anticancer pgm compounds

被引：21
作者：
Barnard, Christopher
机构：
[1] Stoke Row, Oxfordshire
来源：
JOHNSON MATTHEY TECHNOLOGY REVIEW | 2017年 / 61卷 / 01期
关键词：
IN-VITRO; PHASE-II; RUTHENIUM COMPLEXES; ANTITUMOR-ACTIVITY; DRUGS; DNA; RECOGNITION; AGENTS; TRIAL; CIS;
D O I：
10.1595/205651317X693624
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
It was some 50 years ago that Barnett Rosenberg and coworkers published their studies on unusual patterns of bacterial growth that led to the identification of platinum compounds as highly effective agents against some cancers, particularly those of genitourinary origin. This sparked a renewed interest around the world in the potential of metal compounds as small molecule therapeutic agents. Some of that history, particularly related to the platinum group metals (pgm) platinum and ruthenium, is described in this overview.
引用
收藏
页码：52 / 59
页数：8
相关论文
共 47 条
[1]   Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis [J].
Ang, Wee Han ;
Daldini, Elisa ;
Scolaro, Claudine ;
Scopelliti, Rosario ;
Juillerat-Jeannerat, Lucienne ;
Dyson, Paul J. .
INORGANIC CHEMISTRY, 2006, 45 (22) :9006-9013
[2]  
BARNARD CFJ, 1986, CHEM BRIT, V22, P1001
[3]   Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs [J].
Bergamo, Alberta ;
Sava, Gianni .
DALTON TRANSACTIONS, 2011, 40 (31) :7817-7823
[4]  
BOUGHATTAS NA, 1989, CANCER RES, V49, P3362
[5]   Half-sandwich RuII-[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds:: Preparation, structural characterization and in vitro cytotoxic activity [J].
Bratsos, Ioannis ;
Jedner, Stephanie ;
Bergamo, Alberta ;
Sava, Gianni ;
Gianferrara, Teresa ;
Zangrando, Ennio ;
Alessio, Enzo .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102 (5-6) :1120-1133
[6]  
CHRISTIAN MC, 1992, SEMIN ONCOL, V19, P720
[7]  
Clarke MJ., 1980, Metal Ions in Biological Systems, V11, P231
[8]   Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)-Arene Complex [J].
Clavel, Catherine M. ;
Paunescu, Emilia ;
Nowak-Sliwinska, Patrycja ;
Griffioen, Arjan W. ;
Scopelliti, Rosario ;
Dyson, Paul J. .
JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (08) :3546-3558
[9]   TRANSITION-METAL COMPLEXES IN CANCER CHEMOTHERAPY [J].
CLEARE, MJ .
COORDINATION CHEMISTRY REVIEWS, 1974, 12 (04) :349-405
[10]  
Cleare MJ., 1973, BIOINORG CHEM, V2, P187, DOI [https://doi.org/10.1016/S0006-3061(00)80249-5, DOI 10.1016/S0006-3061(00)80249-5]
12345