Pulmonary Tumor Thrombotic Microangiopathy Caused by Urothelial Carcinoma Expressing Vascular Endothelial Growth Factor, Platelet-derived Growth Factor, and Osteopontin

被引：11
作者：
Wakabayashi, Yasushi [1 ]
Iwaya, Mai [2 ]
Akita, Mayo [1 ]
Takeuchi, Wataru [1 ]
Yamazaki, Kyohei [1 ]
Iijima, Akihiro [1 ]
机构：
[1] Nagano Prefectural Kiso Hosp, Dept Internal Med, Kiso, Japan
[2] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan
来源：
INTERNAL MEDICINE | 2016年 / 55卷 / 06期
关键词：
pulmonary tumor thrombotic microangiopathy; urothelial carcinoma; vascular endothelial growth factor; platelet-derived growth factor; osteopontin; GASTRIC-CARCINOMA; TISSUE FACTOR; HYPERTENSION;
D O I：
10.2169/internalmedicine.55.5758
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related pulmonary complication. It is generally caused by gastric adenocarcinoma, and several molecules produced by tumor cells are reported to play important roles in its pathogenesis. We herein report an autopsy case of PTTM caused by urothelial carcinoma. Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and osteopontin were found to be expressed in both the primary tumor cells and metastatic cells in the PTTM lesions. These findings implicate the possible involvement of VEGF, PDGF, and osteopontin in the pathogenesis of PTTM caused by urothelial carcinoma.
引用
收藏
页码：651 / 656
页数：6
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