Circular RNA in pancreatic cancer: a novel avenue for the roles of diagnosis and treatment

被引：79
作者：
Rong, Zeyin [1 ,2 ,3 ,4 ]
Xu, Jin [1 ,2 ,3 ,4 ]
Shi, Si [1 ,2 ,3 ,4 ]
Tan, Zhen [1 ,2 ,3 ,4 ]
Meng, Qingcai [1 ,2 ,3 ,4 ]
Hua, Jie [1 ,2 ,3 ,4 ]
Liu, Jiang [1 ,2 ,3 ,4 ]
Zhang, Bo [1 ,2 ,3 ,4 ]
Wang, Wei [1 ,2 ,3 ,4 ]
Yu, Xianjun [1 ,2 ,3 ,4 ]
Liang, Chen [1 ]
机构：
[1] Fudan Univ, Dept Pancreat Surg, Shanghai Canc Ctr, 270 Dong An Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China
[3] Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China
[4] Shanghai Pancreat Canc Inst, Shanghai 200032, Peoples R China
来源：
THERANOSTICS | 2021年 / 11卷 / 06期
基金：
中国国家自然科学基金; 美国国家科学基金会;
关键词：
Circular RNA; pancreatic cancer; sponge function; biomarker; treatment; DUCTAL ADENOCARCINOMA; NONCODING RNAS; MESSENGER-RNA; TRANSLATION; DATABASE; GEMCITABINE; EXPRESSION; BIOMARKER; CIRCRNA; CELLS;
D O I：
10.7150/thno.56174
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs), a class of endogenous ncRNAs with unique covalently closed loops, have attracted great attention in regard to various diseases, especially cancers. Compelling studies have suggested that circRNAs are aberrantly expressed in different cancer tissues and cell types, including PC. More specifically, circRNAs can modify the proliferation, progression, tumorigenesis and chemosensitivity of PC, and some circRNAs could serve as biomarkers for diagnosis and prognosis. Herein, we summarize what is currently known to be related to the biogenesis, functions and potential roles of human circRNAs in PC and their application prospects for PC clinical treatments.
引用
收藏
页码：2755 / 2769
页数：15
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