New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase

被引：45

作者：

Bonnet, B ^{[1
]}

Soullez, D ^{[1
]}

DavioudCharvet, E ^{[1
]}

Landry, V ^{[1
]}

Horvath, D ^{[1
]}

Sergheraert, C ^{[1
]}

机构：

[1] INST PASTEUR,FAC PHARM,LAB CHIM BIOMOL,CNRS,URA 1309,F-59019 LILLE,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(97)00070-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cnizi trypanothione reductase. IC50 values were assessed between 0.3 and 3 mu M. Compound 32 (K-i = 0.4 mu M) is the most potent TR inhibitor described so far. (C) 1997 Elsevier Science Ltd.

引用

页码：1249 / 1256

页数：8

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