Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel

被引：140

作者：

Navon-Venezia, Shiri

Chmelnitsky, Inna

Leavitt, Azita

Schwaber, Mitchell J.

Schwartz, David

Carmeli, Yehuda

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Div Epidemiol, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Lab Mol Epidemiol & Antiobiot Res, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 09期

关键词：

D O I：

10.1128/AAC.00438-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

引用

页码：3098 / 3101

页数：4

共 21 条

[1]

Arakawa Y, 2000, J CLIN MICROBIOL, V38, P40

[2] Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY:: molecular epidemiology and in vitro activity of polymyxin B and other agents [J].

Bratu, S ;

Tolaney, P ;

Karumudi, U ;

Quale, J ;

Mooty, M ;

Nichani, S ;

Landman, D .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) :128-132

[3] Detection of KPC carbapenem-hydrolyzing enzymes in Enterobacter spp. from Brooklyn, New York [J].

Bratu, S ;

Landman, D ;

Alam, M ;

Tolentino, E ;

Quale, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :776-778

[4] Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City -: A new threat to our antibiotic armamentarium [J].

Bratu, S ;

Landman, D ;

Haag, R ;

Recco, R ;

Eramo, A ;

Alam, M ;

Quale, J .

ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (12) :1430-1435

[5] CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel [J].

Chmelnitsky, I ;

Carmeli, Y ;

Leavitt, A ;

Schwaber, MJ ;

Navon-Venezia, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (11) :4745-4750

[6] First identification of an Escherichia coli clinical isolate producing both metallo-β-lactamase VIM-2 and extended-spectrum β-lactamase IBC-1 [J].

Galani, I ;

Souli, M ;

Chryssouli, Z ;

Katsala, D ;

Giamarellou, H .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (08) :757-760

[7] Escherichia coli:: Development of carbapenem resistance during therapy [J].

Hong, T ;

Moland, ES ;

Abdalhamid, B ;

Hanson, ND ;

Wang, J ;

Sloan, C ;

Fabian, D ;

Faraiallah, A ;

Levine, J ;

Thomson, KS .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (10) :E84-E86

[8] Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 in an Enterobacter sp. [J].

Hossain, A ;

Ferraro, MJ ;

Pino, RM ;

Dew, RB ;

Moland, ES ;

Lockhart, TJ ;

Thomson, KS ;

Goering, RV ;

Hanson, ND .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (11) :4438-4440

[9] Role of β-lactamases and porins in resistance to ertapenem and other β-lactams in Klebsiella pneumoniae [J].

Jacoby, GA ;

Mills, DM ;

Chow, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (08) :3203-3206

[10] USE OF ANALYTICAL ISOELECTRIC FOCUSING FOR DETECTION AND IDENTIFICATION OF BETA-LACTAMASES [J].

MATTHEW, M ;

HARRIS, AM ;

MARSHALL, MJ ;

ROSS, GW .

JOURNAL OF GENERAL MICROBIOLOGY, 1975, 88 (MAY) :169-178

← 1 2 3 →