Spirooxindole synthesis via palladium-catalyzed dearomative reductive-Heck reaction

被引：59

作者：

Liu, Ren-Rong ^{[1
]}

Xu, Yang ^{[1
]}

Liang, Ren-Xiao ^{[1
]}

Xiang, Bin ^{[1
]}

Xie, Hu-Jun ^{[2
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Gongshang Univ, Dept Appl Chem, Hangzhou 310035, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 13期

基金：

中国国家自然科学基金;

关键词：

INTRAMOLECULAR DEAROMATIZATION; ASYMMETRIC DEAROMATIZATION; HIGHLY EFFICIENT; INDOLES; OXINDOLES; DERIVATIVES; CONSTRUCTION; CYCLIZATION; ARYLATION; FUNCTIONALIZATION;

D O I：

10.1039/c7ob00146k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed intramolecular dearomative reductive-Heck reaction of C2- substituted indoles is developed, which provides access to structurally diverse 3,2'-spiropyrrolidine oxindoles. By changing the hydride source to AcONa base, direct C3-arylation products [2,3-b] quinolinones are achieved in good yields. The reaction of C2-substituted benzofuran is also realized, delivering the desired spiro-product.

引用

页码：2711 / 2715

页数：5

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