Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces

被引：163

作者：

Zhou, Zijian ^{[1
,2
]}

Zhao, Zhenghuan ^{[1
,2
]}

Zhang, Hui ^{[1
,2
]}

Wang, Zhenyu ^{[3
,4
]}

Chen, Xiaoyuan ^{[5
]}

Wang, Ruifang ^{[3
,4
]}

Chen, Zhong ^{[3
,4
]}

Gao, Jinhao ^{[1
,2
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Dept Elect Sci, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Fujian Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China

[5] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

来源：

ACS NANO | 2014年 / 8卷 / 08期

基金：

中国国家自然科学基金;

关键词：

T-1 and T-2 contrasts; magnetite nanoplates; Fe3O4(111); morphology; IRON-OXIDE NANOPARTICLES; PAIR CORRELATION-FUNCTIONS; TRANSLATIONAL DIFFUSION; SPIN RELAXATION; AGENTS; WATER; RELAXIVITY; GADOLINIUM; DESIGN; SIZE;

D O I：

10.1021/nn5038652

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron oxide has been developed as either T-1 or T-2 magnetic resonance imaging (MRI) contrast agents by controlling the size and composition; however, the underlying mechanism of T-1 and T-2 contrasts in one iron oxide entity is still not well understood. Herein, we report that freestanding superparamagnetic magnetite nanoplates with (111) exposed facets have significant but interactional T-1 and T-2 contrast effects. We demonstrate that the main contribution of the T-1 contrast of magnetic nanoplates is the chemical exchange on the iron-rich Fe3O4(111) surfaces, whereas the T-2 relaxation is dominated by the intrinsic superparamagnetism of the nanoplates with an enhanced perturbation effect We are able to regulate the balance of T-1 and T-2 contrasts by controlling structure and surface features, including morphology, exposed facets, and surface coating. This study provides an insightful understanding on the T-1 and T-2 contrast mechanisms, which is urgently needed to allow more sophisticated design of high-performance MRI contrast agents.

引用

页码：7976 / 7985

页数：10

共 48 条

[1] Theoretical study of the termination of the Fe3O4 (111) surface [J].