Antivirulence Properties of an Antifreeze Protein

被引：36

作者：

Heisig, Martin ^{[1
]}

Abraham, Nabil M. ^{[1
,4
]}

Liu, Lei ^{[1
]}

Neelakanta, Girish ^{[1
]}

Mattessich, Sarah ^{[1
]}

Sultana, Hameeda ^{[1
]}

Shang, Zhengling ^{[1
]}

Ansari, Juliana M. ^{[1
]}

Killiam, Charlotte ^{[1
]}

Walker, Wendy ^{[1
]}

Cooley, Lynn ^{[2
]}

Flavell, Richard A. ^{[3
,4
]}

Agaisse, Herve ^{[5
]}

Fikrig, Erol ^{[1
,4
]}

机构：

[1] Yale Univ, Infect Dis Sect, Dept Internal Med, Sch Med, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

[3] Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06520 USA

[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[5] Yale Univ, Dept Microbial Pathogenesis, Sch Med, New Haven, CT 06520 USA

来源：

CELL REPORTS | 2014年 / 9卷 / 02期

关键词：

STAPHYLOCOCCUS-EPIDERMIDIS; IXODES-SCAPULARIS; MODEL; COLD; DROSOPHILA; INFECTION; SURVIVAL; IMMUNITY; DISEASE; DEVICES;

D O I：

10.1016/j.celrep.2014.09.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type animals administered P1, were resistant to infection, septic shock, or biofilm development on implanted catheter tubing. These data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.

引用

页码：417 / 424

页数：8

共 33 条

[1] Targeting virulence: can we make evolution-proof drugs? [J].

Allen, Richard C. ;

Popat, Roman ;

Diggle, Stephen P. ;

Brown, Sam P. .

NATURE REVIEWS MICROBIOLOGY, 2014, 12 (04) :300-308

[2] Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection [J].

Apidianakis, Yiorgos ;

Rahme, Laurence G. .

NATURE PROTOCOLS, 2009, 4 (09) :1285-1294

[3] Hibernation is associated with depression of T-cell independent humoral immune responses in the 13-lined ground squirrel [J].

Bouma, Hjalmar R. ;

Henning, Robert H. ;

Kroese, Frans G. M. ;

Carey, Hannah V. .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 39 (03) :154-160

[4]

Boutilier RG, 2001, J EXP BIOL, V204, P3171

[5]

Bownes M, 1989, GENET RES, DOI DOI 10.1017/S0016672300028895

[6] A climate-based model predicts the spatial distribution of the Lyme disease vector Ixodes scapularis in the United States [J].

Brownstein, JS ;

Holford, TR ;

Fish, D .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2003, 111 (09) :1152-1157

[7] Antifreeze glycoprotein agents: structural requirements for activity [J].

Carvajal-Rondanelli, Patricio A. ;

Marshall, Sergio H. ;

Guzman, Fanny .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2011, 91 (14) :2507-2510

[8]

Cassat J.E., 2007, METHICILLIN RESISTA, P113

[9] ADHERENCE OF COAGULASE-NEGATIVE STAPHYLOCOCCI TO PLASTIC TISSUE-CULTURE PLATES - A QUANTITATIVE MODEL FOR THE ADHERENCE OF STAPHYLOCOCCI TO MEDICAL DEVICES [J].

CHRISTENSEN, GD ;

SIMPSON, WA ;

YOUNGER, JJ ;

BADDOUR, LM ;

BARRETT, FF ;

MELTON, DM ;

BEACHEY, EH .

JOURNAL OF CLINICAL MICROBIOLOGY, 1985, 22 (06) :996-1006

[10] The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation [J].

Cramton, SE ;

Gerke, C ;

Schnell, NF ;

Nichols, WW ;

Götz, F .

INFECTION AND IMMUNITY, 1999, 67 (10) :5427-5433

← 1 2 3 4 →