Drug repositioning: auranofin as a prospective antimicrobial agent for the treatment of severe staphylococcal infections

被引：70

作者：

Cassetta, Maria Iris ^{[1
]}

Marzo, Tiziano ^{[2
]}

Fallani, Stefania ^{[1
]}

Novelli, Andrea ^{[1
]}

Messori, Luigi ^{[2
]}

机构：

[1] Univ Florence, Dept Hlth Sci, I-50139 Florence, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy

来源：

BIOMETALS | 2014年 / 27卷 / 04期

关键词：

Auranofin; Antimicrobial drugs; Gold compounds; Drug repositioning; Staphyloccocal infections; CYTOKINES; COMPLEXES;

D O I：

10.1007/s10534-014-9743-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Auranofin, (AF), a gold(I) complex in clinical use for the therapy of rheumatoid arthritis, is reported here to produce remarkable bactericidal effects in vitro against Staphylococcus sp. Noticeably, a similar antimicrobial action and potency are also noticed toward a few methicillin-resistant Staphylococcus aureus strains but not toward Escherichia coli. The time and concentration dependencies of the antimicrobial actions of AF have been characterized through recording time kill curves, and a concentration dependent profile highlighted. Overall, the present results point out that auranofin might be quickly and successfully repurposed for the treatment of severe bacterial infections due to resistant Staphylococci.

引用

页码：787 / 791

页数：5

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