Prostate Cancer Stem Cells: Research Advances

被引：45
作者：
Jaworska, Dagmara [1 ]
Krol, Wojciech [1 ]
Szliszka, Ewelina [1 ]
机构：
[1] Med Univ Silesia, Sch Med, Div Dent Zabrze, Dept Microbiol & Immunol, PL-41808 Zabrze, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 11期
关键词：
cancer stem cell; prostate cancer; metastasis; castration-resistant prostate cancer; EPITHELIAL-MESENCHYMAL TRANSITION; ANDROGEN RECEPTOR; DIFFERENTIAL EXPRESSION; BONE-MARROW; PROSPECTIVE IDENTIFICATION; HEMATOPOIETIC STEM; INITIATING CELLS; DRUG-RESISTANCE; OVARIAN-CANCER; BASAL-CELLS;
D O I：
10.3390/ijms161126036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer stem cells have been defined as cells within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. Experimental evidence showed that these highly tumorigenic cells might be responsible for initiation and progression of cancer into invasive and metastatic disease. Eradicating prostate cancer stem cells, the root of the problem, has been considered as a promising target in prostate cancer treatment to improve the prognosis for patients with advanced stages of the disease.
引用
收藏
页码：27433 / 27449
页数：17
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