Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCζ/SP1 pathway in THP-1 macrophages

被引：18

作者：

Wu, Jian-Feng ^{[1
,2
]}

Wang, Yan ^{[1
,3
]}

Zhang, Min ^{[2
]}

Tang, Yan-Yan ^{[2
]}

Wang, Bo ^{[1
]}

He, Ping-Ping ^{[2
]}

Lv, Yun-Cheng ^{[2
]}

Ouyang, Xin-Ping ^{[2
]}

Yao, Feng ^{[2
]}

Tan, Yu-Lin ^{[2
]}

Tang, Shi-Lin ^{[4
]}

Tang, Deng-Pei ^{[5
]}

Cayabyab, Francisco S. ^{[6
]}

Zheng, Xi-Long ^{[7
]}

Zhang, Da-Wei ^{[8
,9
]}

Zeng, Gao-Feng ^{[1
]}

Tang, Chao-Ke ^{[2
]}

机构：

[1] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China

[3] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China

[4] Univ South China, Affiliated Hosp 2, Dept Intens Care Unit, Hengyang 421001, Hunan, Peoples R China

[5] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7H 5E5, Canada

[6] Univ Saskatchewan, Dept Physiol, Saskatoon, SK 57H 5E5, Canada

[7] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Calgary, AB 72N 4N1, Canada

[8] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada

[9] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 444卷 / 03期

关键词：

GDF-15; Cholesterol efflux; ABCA1; Atherosclerosis; LIVER X RECEPTOR; CHOLESTEROL EFFLUX; SIGNALING PATHWAY; ABCA1; EXPRESSION; LXR-ALPHA; PROTECTS; ATHEROSCLEROSIS; ACTIVATION; INDUCTION; CYTOKINE;

D O I：

10.1016/j.bbrc.2014.01.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective: The aim of this study was to determine whether ATP-binding cassette transporter A1 (ABCA1) was up-regulated by growth differentiation factor-15 (GDF-15) via the phosphoinositide 3-kinase (PI3K)/protein kinase C zeta (PKc zeta)/specificity protein 1 (SP1) pathway in THP-1 macrophages. Methods and results: We investigated the effects of different concentrations of GDF-15 on ABCA1 expression in THP-1 macrophages. The results showed that GDF-15 dramatically increased cholesterol efflux and decreased cellular cholesterol levels. In addition, GDF15 increased ABCA1 mRNA and protein levels. The effects of GDF-15 on ABCA1 protein expression and cellular cholesterol efflux were abolished by wither inhibition or depletion of PI3K, PKC zeta and SP1, respectively, suggesting the potential roles of PI3K, PKC zeta and SP1 in ABCA1 expression. Taken together, GDF-15 appears to activate PI3K, PKq and SP1 cascade, and then increase ABCA1 expression, thereby promoting cholesterol efflux and reducing foam cell formation. Conclusion: Our results suggest that GDF-15 has an overall protective effect on the progression of atherosclerosis, likely through inducing ABCA1 expression via the PI3K/PKC zeta/SP1 signaling pathway and enhancing cholesterol efflux. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：325 / 331

页数：7

共 40 条

[31] Kaempferol suppresses lipid accumulation in macrophages through the downregulation of cluster of differentiation 36 and the upregulation of scavenger receptor class B type I and ATP-binding cassette transporters A1 and G1 [J].

Li, Xiu-Ying ;

Kong, Ling-Xi ;

Li, Juan ;

He, Hai-Xia ;

Zhou, Yuan-Da .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 31 (02) :331-338

[32] Ubiquitination Is Associated with Lysosomal Degradation of Cell Surface-Resident ATP-Binding Cassette Transporter A1 (ABCA1) Through the Endosomal Sorting Complex Required for Transport (ESCRT) Pathway [J].

Mizuno, Tadahaya ;

Hayashi, Hisamitsu ;

Naoi, Sotaro ;

Sugiyama, Yuichi .

HEPATOLOGY, 2011, 54 (02) :631-643

[33] Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells [J].

Dong, Tao ;

Lyu, Jingya ;

Imachi, Hitomi ;

Kobayashi, Toshihiro ;

Fukunaga, Kensaku ;

Sato, Seisuke ;

Ibata, Tomohiro ;

Yoshimoto, Takuo ;

Yonezaki, Kazuko ;

Iwama, Hisakazu ;

Zhang, Guoxing ;

Murao, Koji .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 838 :78-84

[34] Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1 [J].

Ma, Loretta ;

Dong, Fumin ;

Denis, Maxime ;

Feng, Ying ;

Wang, Ming-Dong ;

Zha, Xiaohui .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (05) :3370-3378

[35] ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages [J].

Jiang, Yueqing ;

Kou, Jiayuan ;

Han, Xiaobo ;

Li, Xuesong ;

Zhong, Zhaoyu ;

Liu, Zhongni ;

Zheng, Yinghong ;

Tian, Ye ;

Yang, Liming .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017

[36] miR-33-5p knockdown attenuates abdominal aortic aneurysm progression via promoting target adenosine triphosphate-binding cassette transporter A1 expression and activating the PI3K/Akt signaling pathway [J].

Zhao, Lingfeng ;

Huang, Jian ;

Zhu, Yancui ;

Han, Shengbin ;

Qing, Kaixiong ;

Wang, Jin ;

Feng, Yaoyu .

PERFUSION-UK, 2020, 35 (01) :57-65

[37] House dust mite extract induces growth factor expression in nasal mucosa by activating the PI3K/Akt/HIF-1α pathway [J].

Chen, Xi ;

Li, Ying-Ying ;

Zhang, Wei-Qiang ;

Zhang, Wei-Ming ;

Zhou, Han .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (04) :1055-1061

[38] Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells [J].

Tsai, Chi-Neu ;

Tsai, Chia-Lung ;

Yi, Jui-Shan ;

Kao, Huang-Kai ;

Huang, Yenlin ;

Wang, Chun-I ;

Lee, Yun-Shien ;

Chang, Kai-Ping .

SCIENTIFIC REPORTS, 2019, 9 (1)

[39] Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway [J].

Chen, Hsien-Te ;

Tsou, Hsi-Kai ;

Chang, Chia-Hao ;

Tang, Chih-Hsin .

PLOS ONE, 2012, 7 (06)

[40] Insulin-like growth factor-1 inhibits the apoptosis of rat gastric smooth muscle cells cultured under high glucose condition through PI3K-Akt-PKC-Ca2+ pathway [J].

Fang, Xue-Sen ;

Zhang, Mo-Han ;

Zhang, Xiang-Zi ;

Guo, Jun-Yu ;

Jin, Zheng .

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2019, 33 (01) :456-464

← 1 2 3 4 →