Conservation of transgene-induced post-transcriptional gene silencing in plants and fungi

被引：56

作者：

Cogoni, C ^{[1
]}

Macino, G ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO BIOTECN CELLULARI & EMATOL,SEZ GENET MOL,POLICLIN UMBERTO I,I-00161 ROME,ITALY

来源：

TRENDS IN PLANT SCIENCE | 1997年 / 2卷 / 11期

关键词：

D O I：

10.1016/S1360-1385(97)90028-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Different types of post-transcriptional transgene-induced gene silencing have been shown to occur in Neurospora (quelling) and plants (co-suppression). Common mechanistic features include triggering by duplicated coding sequences, simultaneous silencing of the transgene and endogenous genes, reversibility of silencing, and post-transcriptional reduction of gene-specific mRNA. These shared features suggest that this type of gene silencing may have evolved from a common ancestral mechanism designed to protect genome integrity. Understanding the mechanisms involved may be particularly useful in biotechnological applications aimed at enhancing or avoiding gene silencing in transgenic plants and fungi.

引用

页码：438 / 443

页数：6

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