Pulmonary hyperpolarized noble gas MRI: Recent advances and perspectives in clinical application

被引：34

作者：

Liu, Zaiyi ^{[1
,2
]}

Araki, Tetsuro ^{[1
]}

Okajima, Yuka ^{[1
]}

Albert, Mitchell ^{[3
]}

Hatabu, Hiroto ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Ctr Pulm Funct Imaging,Med Sch, Boston, MA 02115 USA

[2] Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China

[3] Lakehead Univ, Thunder Bay Reg Res Inst, Hyperpolarized Gas MRI Lab, Thunder Bay, ON P7B 5E1, Canada

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2014年 / 83卷 / 07期

关键词：

Hyperpolarized noble gas; MRI; He-3; Xe-129; Lung ventilation image; APPARENT DIFFUSION-COEFFICIENT; AIR-FLOW OBSTRUCTION; INDUCED LUNG INJURY; HE-3; MR; VENTILATION DEFECTS; HEALTHY-VOLUNTEERS; QUANTITATIVE ASSESSMENT; COMPUTED-TOMOGRAPHY; PARTIAL-PRESSURE; ASTHMA;

D O I：

10.1016/j.ejrad.2014.04.014

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The invention of hyperpolarized (HP) noble gas MRI using helium-3 (He-3) or xenon-129 (Xe-129) has provided a new method to evaluate lung function. Using HP 3He or 129Xe for inhalation into the lung air spaces as an MRI contrast agent significantly increases MR signal and makes pulmonary ventilation imaging feasible. This review focuses on important aspects of pulmonary HP noble gas MRI, including the following: (1) functional imaging types, (2) applications for major pulmonary diseases, (3) safety considerations, and (4) future directions. Although it is still challenging to use pulmonary HP noble gas MRI clinically, the technology offers promise for the investigation of the microstructure and function of the lungs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1282 / 1291

页数：10

共 91 条

[41] Imaging of lung ventilation and respiratory dynamics in a single ventilation cycle using hyperpolarized he-3 MRI [J].