An efficient, large-scale synthesis of cytenamide

被引：2

作者：

Bedford, Colin T. ^{[1
]}

机构：

[1] UCL, Christopher Ingold Lab, Dept Chem, London WC1H 0AJ, England

来源：

JOURNAL OF CHEMICAL RESEARCH | 2018年 / 03期

关键词：

cytenamide; dibenzosuberenone; 5H-dibenzo[a; d; cyclohepten-5-one; 5H-5-chlorodibenzo[a; cycloheptene; 5H-5-cyanodibenzo[a; d]cycloheptene; d]cyclo heptene-5-carboxamide; ACID SOLVATE; INHIBITORS;

D O I：

10.3184/174751918X15218087557053

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dibenzosuberenone (5H-dibenzo[a,d] cyclohepten-5-one) was reduced to the corresponding alcohol by sodium borohydride/MeOH and converted to the corresponding 5-chloro compound by thionyl chloride/benzene, treatment of which with CuCN/toluene gave the corresponding nitrile. Hydrolysis by ethanolic KOH yielded the corresponding amide, cytenamide (5H-dibenzo[a,d]cycloheptene-5carboxamide).

引用

页码：153 / 155

页数：3

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