Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

被引：21

作者：

Belletti, B ^{[1
]}

Drakas, R ^{[1
]}

Morrione, A ^{[1
]}

Tu, X ^{[1
]}

Prisco, M ^{[1
]}

Yuan, T ^{[1
]}

Casaburi, I ^{[1
]}

Baserga, R ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2002年 / 277卷 / 01期

关键词：

D O I：

10.1006/excr.2002.5542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activated type I insulin-like growth factor (IGF-IR) increases the expression of Id1 proteins in mouse embryo fibroblasts (MEF). Up-regulation depends on a functional receptor and on multiple pathways originating from different domains of the receptor. In MEF, Id1 protein expression is also up-regulated by serum and certain oncogenes. Signaling through Stat3 plays an important, but not exclusive, role in the up-regulation of Id1 protein levels. In all instances, the increase in Id1 protein expression is paralleled by a corresponding increase in Id1 promoter activity, as measured with a reporter gene. (C) 2002 Elsevier Science (USA).

引用

页码：107 / 118

页数：12

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