Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

被引：21

作者：

Belletti, B ^{[1
]}

Drakas, R ^{[1
]}

Morrione, A ^{[1
]}

Tu, X ^{[1
]}

Prisco, M ^{[1
]}

Yuan, T ^{[1
]}

Casaburi, I ^{[1
]}

Baserga, R ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2002年 / 277卷 / 01期

关键词：

D O I：

10.1006/excr.2002.5542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The activated type I insulin-like growth factor (IGF-IR) increases the expression of Id1 proteins in mouse embryo fibroblasts (MEF). Up-regulation depends on a functional receptor and on multiple pathways originating from different domains of the receptor. In MEF, Id1 protein expression is also up-regulated by serum and certain oncogenes. Signaling through Stat3 plays an important, but not exclusive, role in the up-regulation of Id1 protein levels. In all instances, the increase in Id1 protein expression is paralleled by a corresponding increase in Id1 promoter activity, as measured with a reporter gene. (C) 2002 Elsevier Science (USA).

引用

页码：107 / 118

页数：12

共 54 条

[31] Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts [J].

Lyden, D ;

Young, AZ ;

Zagzag, D ;

Yan, W ;

Gerald, W ;

O'Reilly, R ;

Bader, BL ;

Hynes, RO ;

Zhuang, Y ;

Manova, K ;

Benezra, R .

NATURE, 1999, 401 (6754) :670-677

[32] STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line [J].

Minami, M ;

Inoue, M ;

Wei, S ;

Takeda, K ;

Matsumoto, M ;

Kishimoto, T ;

Akira, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :3963-3966

[33] DIFFERENT EFFECTS ON MITOGENESIS AND TRANSFORMATION OF A MUTATION AT TYROSINE-1251 OF THE INSULIN-LIKE GROWTH-FACTOR-I RECEPTOR [J].

MIURA, M ;

SURMACZ, E ;

BURGAUD, JL ;

BASERGA, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (38) :22639-22644

[34] A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells [J].

Nakajima, K ;

Yamanaka, Y ;

Nakae, K ;

Kojima, H ;

Ichiba, M ;

Kiuchi, N ;

Kitaoka, T ;

Fukada, T ;

Hibi, M ;

Hirano, T .

EMBO JOURNAL, 1996, 15 (14) :3651-3658

[35] Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene [J].

Nehlin, JO ;

Hara, E ;

Kuo, WL ;

Collins, C ;

Campisi, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 231 (03) :628-634

[36]

Nickoloff BJ, 2000, J BIOL CHEM, V275, P27501

[37] Id helix-loop-helix proteins in cell growth and differentiation [J].

Norton, JD ;

Deed, RW ;

Craggs, G ;

Sablitzky, F .

TRENDS IN CELL BIOLOGY, 1998, 8 (02) :58-65

[38] Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis [J].

Peruzzi, F ;

Prisco, M ;

Dews, M ;

Salomoni, P ;

Grassilli, E ;

Romano, G ;

Calabretta, B ;

Baserga, R .

MOLECULAR AND CELLULAR BIOLOGY, 1999, 19 (10) :7203-7215

[39] Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4 [J].

Peruzzi, F ;

Prisco, M ;

Morrione, A ;

Valentinis, B ;

Baserga, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :25990-25996

[40] Regulation of id gene expression by type I insulin-like growth factor: Roles of STAT3 and the tyrosine 950 residue of the receptor [J].

Prisco, M ;

Peruzzi, F ;

Belletti, B ;

Baserga, R .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (16) :5447-5458

← 1 2 3 4 5 6 →