Antioxidative Effect of Quetiapine on Acute Ultraviolet-B-Induced Skin and HaCaT Cell Damage

被引:11
作者
Xu, Pengcheng [1 ]
Zhang, Min [1 ]
Wang, Xueer [1 ]
Yan, Yuan [1 ]
Chen, Yinghua [1 ]
Wu, Wei [1 ]
Zhang, Lu [2 ]
Zhang, Lin [1 ]
机构
[1] Southern Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Key Lab Construct & Detect Tissue Engn Guangdong, 1023-1063 Sha Tai Rd, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Sch Basic Med Sci, Dept Pathophysiol, Key Lab Funct Prote Guangdong Prov, Guangzhou 510515, Guangdong, Peoples R China
关键词
UVB; quetiapine; acute photodamage; p-p38; oxidative stress; INDUCED OXIDATIVE STRESS; INFLAMMATORY RESPONSE; PROTECTS SKIN; DNA-DAMAGE; KERATINOCYTES; UVB; APOPTOSIS; P38; IRRADIATION; RADIATION;
D O I
10.3390/ijms19040953
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quetiapine is a new type of antipsychotic drug, with effective protection of pheochromocytoma PC12 cells from oxidative stress-induced apoptosis. Ultraviolet-B radiation can increase reactive oxygen species (ROS) production, resulting in significant inflammatory responses in damaged skin. Thus, the purpose of this study is to explore whether quetiapine protects the skin from intermediate-wave ultraviolet (UVB)-induced damage through antioxidant stress. In vivo, we found quetiapine treatment was able to significantly decrease skin thickness, erythema, and edema, as well as inflammation compared to control group. Moreover, quetiapine treatment increased the activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). In addition, it reduced the production of malondialdehyde (MDA), a kind of oxidized lipid. In vitro, we found that quetiapine blocked UVB-induced intracellular ROS generation and maintained the cell activity at a normal level. Furthermore, we tested the phosphorylation of p38 both in vivo and in vitro, and we found that quetiapine could inhibit phosphorylation of p38, which is caused by UVB irradiation. We concluded that quetiapine was able to relieve UVB-induced skin damage through its antioxidative properties. These effects might be associated with p38 MAPK signaling pathway.
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页数:13
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