Biochemical mechanisms of vertebrate hedgehog signaling

被引：192

作者：

Kong, Jennifer H. ^{[1
,2
]}

Siebold, Christian ^{[3
]}

Rohatgi, Rajat ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[3] Univ Oxford, Div Struct Biol, Wellcome Ctr Human Genet, Oxford OX3 7BN, England

来源：

DEVELOPMENT | 2019年 / 146卷 / 10期

基金：

欧洲研究理事会; 美国国家卫生研究院;

关键词：

Cholesterol; Hedgehog signaling; Morphogen; Patched; Primary cilium; Smoothened; PROTEIN-KINASE-A; COUPLED RECEPTOR GPR161; CHOLESTEROL-MODIFIED HEDGEHOG; STEROL-SENSING DOMAIN; MOUSE PATCHED GENE; SONIC-HEDGEHOG; LONG-RANGE; TUMOR-SUPPRESSOR; MULTISITE PHOSPHORYLATION; INTRAFLAGELLAR TRANSPORT;

D O I：

10.1242/dev.166892

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the mechanisms by which the HH signal is received by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs.

引用

页数：17

共 185 条

[141] FLOOR PLATE AND MOTOR-NEURON INDUCTION BY VHH-1, A VERTEBRATE HOMOLOG OF HEDGEHOG EXPRESSED BY THE NOTOCHORD [J].

ROELINK, H ;

AUGSBURGER, A ;

HEEMSKERK, J ;

KORZH, V ;

NORLIN, S ;

ALTABA, ARI ;

TANABE, Y ;

PLACZEK, M ;

EDLUND, T ;

JESSELL, TM ;

DODD, J .

CELL, 1994, 76 (04) :761-775

[142] Patched1 regulates Hedgehog signaling at the primary cilium [J].

Rohatgi, Rajat ;

Milenkovic, Ljiljana ;

Scott, Matthew P. .

SCIENCE, 2007, 317 (5836) :372-376

[143] The ciliary membrane [J].

Rohatgi, Rajat ;

Snell, William J. .

CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (04) :541-546

[144] Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process [J].

Rohatgi, Rajat ;

Milenkovic, Ljiljana ;

Corcoran, Ryan B. ;

Scott, Matthew P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3196-3201

[145] Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning [J].

Sanders, Timothy A. ;

Llagostera, Esther ;

Barna, Maria .

NATURE, 2013, 497 (7451) :628-+

[146] A Three-part Signal Governs Differential Processing of Gli1 and Gli3 Proteins by the Proteasome [J].

Schrader, Erin K. ;

Harstad, Kristine G. ;

Holmgren, Robert A. ;

Matouschek, Andreas .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (45) :39051-39058

[147]

Sharpe HJ, 2015, NAT CHEM BIOL, V11, P246, DOI [10.1038/NCHEMBIO.1776, 10.1038/nchembio.1776]

[148] Smoothened Is a Fully Competent Activator of the Heterotrimeric G Protein Gi [J].

Shen, Feng ;

Cheng, Lan ;

Douglas, Andrew E. ;

Riobo, Natalia A. ;

Manning, David R. .

MOLECULAR PHARMACOLOGY, 2013, 83 (03) :691-697

[149] Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis [J].

Shimada, Issei S. ;

Hwang, Sun-Hee ;

Somatilaka, Bandarigoda N. ;

Wang, Xin ;

Skowron, Patryk ;

Kim, Jiwoong ;

Kim, Min ;

Shelton, John M. ;

Rajaram, Veena ;

Xuan, Zhenyu ;

Taylor, Michael D. ;

Mukhopadhyay, Saikat .

CELL REPORTS, 2018, 22 (05) :1169-1184

[150] A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube [J].

Stamataki, D ;

Ulloa, F ;

Tsoni, SV ;

Mynett, A ;

Briscoe, J .

GENES & DEVELOPMENT, 2005, 19 (05) :626-641

← 10 11 12 13 14 15 16 17 18 19 →