Roles of activin in tissue repair, tibrosis, and inflammatory disease

被引：187
作者：
Werner, Sabine [1 ]
Alzheimer, Christian
机构：
[1] ETH, Inst Cell Biol, Dept Biol, CH-8093 Zurich, Switzerland
[2] Univ Kiel, Dept Physiol, D-24098 Kiel, Germany
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 03期
关键词：
activin; follistatin; inflammation; regeneration; wound healing; apoptosis;
D O I：
10.1016/j.cytogfr.2006.01.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activins are transforming growth factor beta superfamily members. which were originally identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, however, additional functions of activins have been discovered, including a role in the morphogenesis of various tissues and organs. In addition, they have been identified as novel players in inflamination and repair, and are most likely involved in the pathogenesis of inflammatory and fibrotic human diseases. In this review we highlight recent data regarding the expression and function of activins in tissue repair, fibrosis. and inflamation. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：157 / 171
页数：15
相关论文
共 121 条
  • [1] Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts
    Abe, M
    Shintani, Y
    Eto, Y
    Harada, K
    Fujinaka, Y
    Kosaka, M
    Matsumoto, T
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 126 (01) : 64 - 68
  • [2] INDUCTION OF BETA-A ACTIVIN EXPRESSION BY SYNAPTIC ACTIVITY AND DURING NEOCORTICAL DEVELOPMENT
    ANDREASSON, K
    WORLEY, PF
    [J]. NEUROSCIENCE, 1995, 69 (03) : 781 - 796
  • [3] Attenuation of bleomycin-induced pulmonary fibrosis by follistatin
    Aoki, F
    Kurabayashi, M
    Hasegawa, Y
    Kojima, I
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (06) : 713 - 720
  • [4] Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    Ashcroft, GS
    Yang, X
    Glick, AB
    Weinstein, M
    Letterio, JJ
    Mizel, DE
    Anzano, M
    Greenwell-Wild, T
    Wahl, SM
    Deng, CX
    Roberts, AB
    [J]. NATURE CELL BIOLOGY, 1999, 1 (05) : 260 - 266
  • [5] Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes
    Bamberger, C
    Schärer, A
    Antsiferova, M
    Tychsen, B
    Pankow, S
    Müller, M
    Rülicke, T
    Paus, R
    Werner, S
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (03) : 733 - 747
  • [6] Becker JC, 2003, SCAND J GASTROENTERO, V38, P260, DOI 10.1080/00365520310000636
  • [7] THE PLASMACYTOMA GROWTH INHIBITOR RESTRICTIN-P IS AN ANTAGONIST OF INTERLEUKIN-6 AND INTERLEUKIN-11 - IDENTIFICATION AS A STROMA-DERIVED ACTIVIN-A
    BROSH, N
    STERNBERG, D
    HONIGWACHSSHAANANI, J
    LEE, BC
    SHAV-TAL, Y
    TZEHOVAL, E
    SHULMAN, LM
    TOLEDO, J
    HACHAM, Y
    CARMI, P
    JIANG, W
    SASSE, J
    HORN, F
    BURSTEIN, Y
    ZIPORI, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) : 29594 - 29600
  • [8] Caestecker MD, 2004, CYTOKINE GROWTH F R, V15, P1
  • [9] Overexpression of activin βC or activin βE in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells
    Chabicovsky, M
    Herkner, K
    Rossmanith, W
    [J]. ENDOCRINOLOGY, 2003, 144 (08) : 3497 - 3504
  • [10] Activin a-induced HepG2 liver cell apoptosis: Involvement of activin receptors and Smad proteins
    Chen, W
    Woodruff, TK
    Mayo, KE
    [J]. ENDOCRINOLOGY, 2000, 141 (03) : 1263 - 1272
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