The Immunopathology of Cutaneous Lupus Erythematosus

被引：17

作者：

Kirchhof, Mark G. ^{[1
]}

Dutz, Jan P. ^{[1
,2
]}

机构：

[1] Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 4E8, Canada

[2] Univ British Columbia, Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2014年 / 40卷 / 03期

关键词：

Cutaneous lupus erythematosus; Discoid lupus erythematosus; Chemokine; Interferon-alpha; Cytokine; PLASMACYTOID DENDRITIC CELLS; NECROSIS-FACTOR-ALPHA; BLOOD MONONUCLEAR-CELLS; TNF-ALPHA; INTERFERON-ALPHA; SKIN-LESIONS; AUTOANTIBODY PRODUCTION; B-CELLS; INTRAVENOUS IMMUNOGLOBULIN; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.rdc.2014.04.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the development of autoantibodies and immunologic attack of different organ systems, including the skin. This review aims to provide an overview of some of the pathogenic processes that may be important in the development of SLE, specifically cutaneous lupus erythematosus, and then illustrates how therapies might be tailored to modify these processes and treat disease.

引用

页码：455 / +

页数：21

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