An efficient and mild iron-mediated synthesis of alkenyl halides via direct C-C bond formation of benzyl alcohols and aryl alkynes

被引：37

作者：

Liu, Zhong-Quan ^{[1
]}

Wang, Jianguo

Han, Jie

Zhao, Yankai

Zhou, Bo

机构：

[1] Gannan Normal Univ, Inst Organ Chem, Ganzhou 341000, Jiangxi, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 11期

关键词：

ALLYLIC ALCOHOLS; CATALYZED BENZYLATION; ALKYLATION; SUBSTITUTION;

D O I：

10.1016/j.tetlet.2009.01.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work demonstrated an efficient and mild method for preparing various substituted alkenyl halides via direct C-C bond formation of benzyl alcohols and aryl alkynes in CH2Cl2 at 50 degrees*C by using 50 mol % of FeCl3 center dot 6H(2)O or FeBr3. Compared with the systems using excessive boron trihalides and stoichiometric n-BuLi to prepare substituted alkenyl halides, the present procedure would provide an excellent alternative due to the environmentally benign system and atom efficiency. (C) 2009 Elsevier Ltd. All rights reserved

引用

页码：1240 / 1242

页数：3

共 28 条

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