The reproducibility of trophectoderm biopsies - The chaos behind preimplantation genetic testing for aneuploidy

被引：9
|
作者：
Orvieto, Raoul [1 ,2 ,3 ]
机构：
[1] Chaim Sheba Med Ctr Tel Hashomer, Dept Obstet & Gynecol, Infertil & IVF Unit, Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tarnesby Tarnowski Chair Family Planning & Fertil, Tel Aviv, Israel
来源：
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2020年 / 254卷
关键词：
Mosaicism; PGT-A; Trophectoderm; Blastocyst; Screening test;
D O I：
10.1016/j.ejogrb.2020.07.052
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Chromosomal mosaicism is a common feature of early human embryos development. "Mosaic" embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：57 / 58
页数：2
相关论文
共 50 条
  • [31] We have reached a dead end for preimplantation genetic testing for aneuploidy
    Gleicher, Norbert
    Barad, David H.
    Patrizio, Pasquale
    Orvieto, Raoul
    HUMAN REPRODUCTION, 2022, 37 (12) : 2730 - 2734
  • [32] Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts
    McArthur, SJ
    Leigh, D
    Marshall, JT
    de Boer, KA
    Jansen, RPS
    FERTILITY AND STERILITY, 2005, 84 (06) : 1628 - 1636
  • [33] Male factor infertility impacts the rate of mosaic blastocysts in cycles of preimplantation genetic testing for aneuploidy
    Tarozzi, Nicoletta
    Nadalini, Marco
    Lagalla, Cristina
    Coticchio, Giovanni
    Zaca, Carlotta
    Borini, Andrea
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2019, 36 (10) : 2047 - 2055
  • [34] Male factor infertility impacts the rate of mosaic blastocysts in cycles of preimplantation genetic testing for aneuploidy
    Nicoletta Tarozzi
    Marco Nadalini
    Cristina Lagalla
    Giovanni Coticchio
    Carlotta Zacà
    Andrea Borini
    Journal of Assisted Reproduction and Genetics, 2019, 36 : 2047 - 2055
  • [35] Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A): The first Brazilian baby
    Franco Jr, Jose Goncalves
    Vagnini, Laura Diniz
    Petersen, Claudia Guilhermino
    Renzi, Adriana
    Canas, Maria C. T.
    Petersen, Bruna
    Ricci, Juliana
    Nicoletti, Andreia
    Zamara, Camila
    Dieamant, Felipe
    Alcantara Oliveira, Joao Batista
    JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA, 2020, 24 (04): : 1
  • [36] Preimplantation genetic testing for aneuploidy (PGT-A)-a single-center experience
    Nair, Jiny
    Shetty, Sachin
    Kasi, Cynthia Irene
    Thondehalmath, Nirmala
    Ganesh, Deepanjali
    Bhat, Vidyalakshmi R.
    Mannadia, Sajana
    Ranganath, Anjana
    Nayak, Rajsekhar
    Gunasheela, Devika
    Shetty, Swathi
    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2022, 39 (03) : 729 - 738
  • [37] Preimplantation genetic testing for aneuploidy: A review of published blastocyst reanalysis concordance data
    Marin, Diego
    Xu, Jia
    Treff, Nathan R.
    PRENATAL DIAGNOSIS, 2021, 41 (05) : 545 - 553
  • [38] Conditions for improved accuracy of noninvasive preimplantation genetic testing for aneuploidy: Focusing on the zona pellucida and early blastocysts
    Takeuchi, Hiroki
    Morishita, Midori
    Uemura, Midori
    Maezawa, Tadashi
    Shibahara, Takashi
    Takayama, Erina
    Nishioka, Mikiko
    Kondo, Eiji
    Minoura, Hiroyuki
    Ikeda, Tomoaki
    REPRODUCTIVE MEDICINE AND BIOLOGY, 2024, 23 (01)
  • [39] The concordance rates of an initial trophectoderm biopsy with the rest of the embryo using PGTseq, a targeted next-generation sequencing platform for preimplantation genetic testing-aneuploidy
    Kim, Julia
    Tao, Xin
    Cheng, Michael
    Steward, Ayesha
    Guo, Vanessa
    Zhan, Yiping
    Scott Jr, Richard T.
    Jalas, Chaim
    FERTILITY AND STERILITY, 2022, 117 (02) : 315 - 323
  • [40] Transition from blastomere to trophectoderm biopsy: comparing two preimplantation genetic testing for aneuploidies strategies
    Coll, Lluc
    Parriego, Monica
    Boada, Montserrat
    Devesa, Marta
    Arroyo, Gemma
    Rodriguez, Ignacio
    Coroleu, Bonaventura
    Vidal, Francesca
    Veiga, Anna
    ZYGOTE, 2018, 26 (03) : 191 - 198
12345