The reproducibility of trophectoderm biopsies - The chaos behind preimplantation genetic testing for aneuploidy

被引：9
|
作者：
Orvieto, Raoul [1 ,2 ,3 ]
机构：
[1] Chaim Sheba Med Ctr Tel Hashomer, Dept Obstet & Gynecol, Infertil & IVF Unit, Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tarnesby Tarnowski Chair Family Planning & Fertil, Tel Aviv, Israel
来源：
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2020年 / 254卷
关键词：
Mosaicism; PGT-A; Trophectoderm; Blastocyst; Screening test;
D O I：
10.1016/j.ejogrb.2020.07.052
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Chromosomal mosaicism is a common feature of early human embryos development. "Mosaic" embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页码：57 / 58
页数：2
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