Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia

被引：144

作者：

Soverini, Simona ^{[1
]}

Branford, Susan ^{[2
,3
,4
]}

Nicolini, Franck E. ^{[1
,5
]}

Talpaz, Moshe

Deininger, Michael W. N. ^{[6
]}

Martinelli, Giovanni ^{[1
]}

Mueller, Martin C. ^{[7
]}

Radich, Jerald P. ^{[8
]}

Shah, Neil P. ^{[9
]}

机构：

[1] Univ Bologna, S Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[2] SA Pathol, Dept Mol Pathol, Ctr Canc Biol, Adelaide, SA, Australia

[3] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[4] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia

[5] Ctr Hosp Lyon Sud, Hematol Dept 1G, F-69310 Pierre Benite, France

[6] Univ Michigan, Dept Internal Med, Div Hematol & Oncol, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[7] Heidelberg Univ, Med Klin 3, Univ Med Mannheim, Mannheim, Germany

[8] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[9] Univ Calif San Francisco, Dept Hematol Oncol, San Francisco, CA 94143 USA

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 01期

关键词：

BCR-ABL1; Kinase domain; Tyrosine kinase inhibitors; Philadelphia chromosome; Chronic myeloid leukemia; Resistance; Mutations; DIAGNOSED CHRONIC-PHASE; BCR-ABL MUTATIONS; DASATINIB; 100; MG; PHILADELPHIA-POSITIVE PATIENTS; GIMEMA WORKING PARTY; IMATINIB-RESISTANT; FOLLOW-UP; HIGH-RISK; CML; CHROMOSOME;

D O I：

10.1016/j.leukres.2013.09.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with chronic myeloid leukemia develop resistance to both first-generation and second-generation tyrosine kinase inhibitors (TKIs) as a result of mutations in the kinase domain (KD) of BCR-ABL1. A wide range of BCR-ABL1 KD mutations that confer resistance to TKIs have been identified, and the T3151 mutant has proven particularly difficult to target. This review summarizes the prevalence impact, and prognostic implications of BCR-ABL1 KD mutations in patients with chronic myeloid leukemia who are treated with current TKIs and provides an overview of recent treatment guidelines and future trends for the detect of mutatkins. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

引用

页码：10 / 20

页数：11

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