Efficient systemic DNA delivery to the tumor by self-assembled nanoparticle

被引：2
作者：
Tang, Hailin [1 ,2 ]
Xie, Xinhua [1 ]
Guo, Jiaoli [3 ]
Wei, Weidong [1 ]
Wu, Minqing [1 ,2 ]
Liu, Peng [1 ]
Kong, Yanan [1 ,2 ]
Yang, Lu [1 ,2 ]
Hung, Mien-Chie [4 ]
Xie, Xiaoming [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Dept Breast Oncol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China
[3] Fenggang Peoples Hosp, Shenzhen 518000, Peoples R China
[4] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2013年 / 16卷 / 01期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
BikDD; Delivery system; Nanoparticle; XM001; Nanomedicine; ELIMINATES BREAST-CANCER; TARGETED EXPRESSION; GENE-THERAPY;
D O I：
10.1007/s11051-013-2213-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
There are few delivery agents that could deliver gene with high efficiency and low toxicity, especially for animal experiments. Therefore, creating vectors with good delivery efficiency and safety profile is a meaningful work. We have developed a self-assembled gene delivery system (XM001), which can more efficiently deliver DNA to multiple cell lines and breast tumor, as compared to commercial delivery agents. In addition, systemically administrated XM001-BikDD (BikDD is a mutant form of proapoptotic gene Bik) significantly inhibited the growth of human breast cancer cells and prolonged the life span in implanted nude mice. This study demonstrates that XM001 is an efficient and widespread transfection agent, which could be a promising tumor delivery vector for cancer targeted therapy.
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页数：6
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