DNA damage associated with mitosis and cytokinesis failure

被引:120
作者
Hayashi, M. T. [1 ]
Karlseder, J. [1 ]
机构
[1] Salk Inst Biol Studies, Dept Mol & Cellular Biol, La Jolla, CA 92037 USA
基金
日本学术振兴会;
关键词
mitosis; DNA damage; telomeres; checkpoints; cytokinesis; KINETOCHORE-MICROTUBULE ATTACHMENT; ANAPHASE-PROMOTING COMPLEX; DOUBLE-STRAND BREAKS; POLO-LIKE KINASE-1; HUMAN-CELLS; AURORA-B; MITOTIC CHECKPOINT; CHROMOSOME MISSEGREGATION; EXTRA CENTROSOMES; MAMMALIAN-CELLS;
D O I
10.1038/onc.2012.615
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitosis is a highly dynamic process, aimed at separating identical copies of genomic material into two daughter cells. A failure of the mitotic process generates cells that carry abnormal chromosome numbers. Such cells are predisposed to become tumorigenic upon continuous cell division and thus need to be removed from the population to avoid cancer formation. Cells that fail in mitotic progression indeed activate cell death or cell cycle arrest pathways; however, these mechanisms are not well understood. Growing evidence suggests that the formation of de novo DNA damage during and after mitotic failure is one of the causal factors that initiate those pathways. Here, we analyze several distinct malfunctions during mitosis and cytokinesis that lead to de novo DNA damage generation.
引用
收藏
页码:4593 / 4601
页数:9
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