Synthesis of novel hydropyrazolopyridine derivatives in solvent-free conditions via benzotriazole methodology

被引:17
作者
Abonia, R
Rengifo, E
Quiroga, J
Insuasty, B
Cobo, J
Nogueras, M
机构
[1] Univ Valle, Dept Chem, Grupo Invest Compuestos Heteroc, Cali 25360, Colombia
[2] Univ Jaen, Dept Quim Inorgan & Organ, Jaen 23071, Spain
关键词
5-aminopyrazole; hydropyrazolopyridines; benzotriazole; alkenes; cyclization; triaza-indacenes; triaza-cyclopentanaphthalenes;
D O I
10.1016/j.tet.2004.07.028
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The reaction between 5-[N-(benzotriazol-1-ylmethyl)amino]-3-tert-butyl-1-phenylpyrazole or 5-amino-4-(benzotriazol-1-ylmethyl)-3-tert-butyl-1-phenylpyrazole with some unactivated and electron-rich alkenes has followed heterocyclization reactions to yield hydropyrazolopyridines, under solvent-free conditions, as predicted by benzotriazole methodology in contrast with those results obtained under solution. The reaction mechanism was proposed after fully spectroscopic analysis of final products and intermediates. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:8839 / 8843
页数:5
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