Shiga toxin-encoding bacteriophages - genomes in motion

被引：199
作者：
Herold, S
Karch, H
Schmidt, H
机构：
[1] Tech Univ Dresden, Fak Med Carl Gustav Carus, Inst Med Mikrobiol & Hyg, D-01037 Dresden, Germany
[2] Univ Munster, Inst Hyg, D-48149 Munster, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 294卷 / 2-3期
关键词：
shiga toxin-producing E. coli; shiga toxin-encoding bacteriophages; phage induction; transduction; pathogenesis; integration sites; Stx induction;
D O I：
10.1016/j.ijmm.2004.06.023
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Shiga toxins (Stx) represent a group of bacterial toxins that are involved in human and animal disease. Stx are mainly produced by Escherichia coli isolated from human and non-human sources, Shigella dysenteriae type 1, and sporadically, by Citrobacter freundii, Enterobacter cloacae and Shigella flexneri. The genes encoding Stx are encoded in the genome of heterogeneous lambdoid prophages (Stx-converting bacteriophages; Stx-phages). They are located in a similar position in the late region of the prophage genome and stx is under control of phage genes. Therefore, induction of Stx-converting prophages triggers increased production of Stx. Following induction, Stx-phages can infect other bacteria in vivo and in vitro. Stx-phages may be considered to represent highly mobile genetic elements that play an important role in the expression of Stx, in horizontal gene transfer, and hence in genome diversification. (C) 2004 Elsevier GmbH. All rights reserved.
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页码：115 / 121
页数：7
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