Second malignancies in patients treated for Ewing sarcoma: A systematic review

被引：14

作者：

Caruso, Jennifer ^{[1
]}

Shulman, David S. ^{[2
]}

DuBois, Steven G. ^{[2
]}

机构：

[1] Northeastern Univ, Boston, MA 02115 USA

[2] Harvard Med Sch, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA

来源：

PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 11期

关键词：

acute myeloid leukemia; Ewing sarcoma; myelodysplastic syndrome; osteosarcoma; second malignancy; systematic review; LONG-TERM SURVIVORS; CHILDHOOD-CANCER; CHEMOTHERAPY; BONE; RADIOTHERAPY; TUMORS; LEUKEMIA; ADJUVANT; FAMILY; RISK;

D O I：

10.1002/pbc.27938

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapies used to treat Ewing sarcoma are associated with a risk of second malignant neoplasm (SMN). We conducted a systematic review to pool available evidence on the risks, types, and outcomes after SMN. We obtained 52 articles that met inclusion criteria. Cumulative incidence rates of SMN ranged from 0.9 to 8.4% and 10.1 to 20.5% at 5 and 30 years after initial diagnosis. Of the 327 reported SMNs, 63.6% were solid tumors, although acute myeloid leukemia /myelodysplastic syndrome was the single most commonly diagnosed SMN, with generally poor outcomes. Patients treated for Ewing sarcoma are at substantial risk of SMN, with a broad range of reported secondary cancers.

引用

页数：6

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