What is already known about this topic? Surveillance is a cornerstone of polio eradication programs. Acute flaccid paralysis (AFP) surveillance is the primary means of poliovirus detection, supplemented by environmental surveillance (i.e., the collection of sewage samples for poliovirus testing) to identify poliovirus circulation in the absence of detected AFP cases. What is added by this report? Although surveillance performance indicators are improving, gaps remain, including substantial variation at subnational levels (i.e., in 2016, of 20 African Region countries, 19 met the NPAFP target at the national level versus 11 at all subnational levels). The number of environmental surveillance locations has increased substantially (from 21 at the end of 2011 in Afghanistan, Nigeria, and Pakistan to 138 as of February 2017) and has enhanced the ability to detect poliovirus circulation and possible AFP surveillance gaps. In countries previously affected by Ebola, surveillance quality is improving, although further measures are needed to reach preoutbreak levels. What are the implications for public health practice? Rapid improvements in AFP surveillance are needed in several African Region countries to ensure timely certification of polio-free status. Gaps in surveillance quality, especially at the subnational level, need to be identified and resolved through well-supervised active and monitored passive surveillance, and supplemental environmental and virologic surveillance. As long as polioviruses continue to circulate in any country, all countries remain at risk. © 2017, Department of Health and Human Services. All rights reserved.