Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

被引：50
|
作者：
Kapur, Rick [1 ]
Kim, Michael [2 ,3 ]
Rebetz, Johan [1 ,5 ]
Hallstrom, Bjom [4 ]
Bjorkman, Jonas T.
Takabe-French, Alisa [2 ,3 ]
Kim, Noel [2 ,3 ]
Liu, Jonathan [2 ,3 ]
Shanmugabhavananthan, Shanjeevan [2 ,3 ]
Milosevic, Stefan [2 ,3 ]
McVey, Mark J. [2 ,3 ,6 ,7 ,8 ,9 ]
Speck, Edwin R. [2 ,3 ]
Semple, John W. [1 ,2 ,3 ,6 ,10 ,11 ,12 ]
机构：
[1] Lund Univ, Div Hematol & Transfus Med, Lund, Sweden
[2] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada
[3] St Michaels Hosp, Toronto Platelet Immunobiol Grp, Toronto, ON, Canada
[4] Lund Univ, Ctr Translat Genom, Lund, Sweden
[5] Skane Univ Hosp, Ctr Mol Diagnost, Lund, Sweden
[6] Canadian Blood Serv, Toronto, ON, Canada
[7] Univ Toronto, Dept Anesthesia, Toronto, ON, Canada
[8] Univ Toronto, Dept Physiol, Toronto, ON, Canada
[9] Hosp Sick Children, Dept Anesthesia & Pain Med, Toronto, ON, Canada
[10] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada
[11] Univ Toronto, Dept Med, Toronto, ON, Canada
[12] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada
来源：
BLOOD ADVANCES | 2018年 / 2卷 / 13期
基金：
瑞典研究理事会;
关键词：
GUT MICROBIOTA; ULCERATIVE-COLITIS; MOUSE MODEL; DISEASE; ANTIBODY; FLORA; HOMEOSTASIS; RECEPTORS; RISK; MICE;
D O I：
10.1182/bloodadvances.2018018903
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion.
引用
收藏
页码：1651 / 1663
页数：13
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