Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury

被引：50

作者：

Kapur, Rick ^{[1
]}

Kim, Michael ^{[2
,3
]}

Rebetz, Johan ^{[1
,5
]}

Hallstrom, Bjom ^{[4
]}

Bjorkman, Jonas T.

Takabe-French, Alisa ^{[2
,3
]}

Kim, Noel ^{[2
,3
]}

Liu, Jonathan ^{[2
,3
]}

Shanmugabhavananthan, Shanjeevan ^{[2
,3
]}

Milosevic, Stefan ^{[2
,3
]}

McVey, Mark J. ^{[2
,3
,6
,7
,8
,9
]}

Speck, Edwin R. ^{[2
,3
]}

Semple, John W. ^{[1
,2
,3
,6
,10
,11
,12
]}

机构：

[1] Lund Univ, Div Hematol & Transfus Med, Lund, Sweden

[2] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada

[3] St Michaels Hosp, Toronto Platelet Immunobiol Grp, Toronto, ON, Canada

[4] Lund Univ, Ctr Translat Genom, Lund, Sweden

[5] Skane Univ Hosp, Ctr Mol Diagnost, Lund, Sweden

[6] Canadian Blood Serv, Toronto, ON, Canada

[7] Univ Toronto, Dept Anesthesia, Toronto, ON, Canada

[8] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[9] Hosp Sick Children, Dept Anesthesia & Pain Med, Toronto, ON, Canada

[10] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[11] Univ Toronto, Dept Med, Toronto, ON, Canada

[12] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada

来源：

BLOOD ADVANCES | 2018年 / 2卷 / 13期

基金：

瑞典研究理事会;

关键词：

GUT MICROBIOTA; ULCERATIVE-COLITIS; MOUSE MODEL; DISEASE; ANTIBODY; FLORA; HOMEOSTASIS; RECEPTORS; RISK; MICE;

D O I：

10.1182/bloodadvances.2018018903

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in the development of TRALI is currently unknown. We observed that untreated barrier-free (BF) mice suffered from severe antibody-mediated acute lung injury, whereas the more sterile housed specific pathogen-free (SPF) mice and gut flora-depleted BF mice were both protected from lung injury. The prevention of TRALI in the SPF mice and gut flora-depleted BF mice was associated with decreased plasma macrophage inflammatory protein-2 levels as well as decreased pulmonary neutrophil accumulation. DNA sequencing of amplicons of the 16S ribosomal RNA gene revealed a varying gastrointestinal bacterial composition between BF and SPF mice. BF fecal matter transferred into SPF mice significantly restored TRALI susceptibility in SPF mice. These data reveal a link between the gut flora composition and the development of antibody-mediated TRALI in mice. Assessment of gut microbial composition may help in TRALI risk assessment before transfusion.

引用

页码：1651 / 1663

页数：13

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