Cysteine-activated hydrogen sulfide (H2S) delivery through caged carbonyl sulfide (COS) donor motifs

被引：64
|
作者：
Zhao, Yu [1 ]
Steiger, Andrea K. [1 ]
Pluth, Michael D. [1 ]
机构：
[1] Univ Oregon, Inst Mol Biol, Mat Sci Inst, Dept Chem & Biochem, Eugene, OR 97403 USA
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 39期
基金：
美国国家科学基金会;
关键词：
SULFUR-DIOXIDE SO2; FLUORESCENT-PROBES; RELEASE; AGENTS; HOMOCYSTEINE; INHIBITION; CHEMISTRY; DONATION;
D O I：
10.1039/c8cc02428f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogen sulfide (H2S) is an important biomolecule, and controllable H2S donors are needed to investigate H2S biological functions. Here we utilize cysteine-mediated addition/cyclization chemistry to unmask an acrylate-functionalized thiocarbamate and release carbonyl sulfide (COS), which is quickly converted to H2S by carbonic anhydrase (CA).
引用
收藏
页码：4951 / 4954
页数：4
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