Hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancies using new hybrid CO2 system: preliminary experience in referral center

被引:18
作者
Cianci, Stefano [1 ]
Abatini, Carlo [2 ]
Fagotti, Anna [3 ]
Chiofalo, Benito [4 ]
Tropea, Alessandro [5 ]
Biondi, Antonio [5 ]
Scambia, Giovanni [3 ]
Pacelli, Fabio [6 ]
机构
[1] Fdn Policlin Univ A Gemelli, Unita Operat Ginecol Oncol, IRCCS, Dipartimento Sci Salute Donna & Bambino, Rome, Italy
[2] Fdn Policlin Univ A Gemelli, IRCCS, Dipartimento Chirurg Gen, Rome, Italy
[3] Univ Cattolica Sacro Cuore, Unita Operat Ginecol Oncol, Dipartimento Sci Salute Donna & Bambino, Fdn Policlin Univ A Gemelli,IRCCS, Rome, Italy
[4] Regina Elena Inst Canc Res, Gynecol Oncol Unit, Dept Expt Clin Oncol, Rome, Italy
[5] Univ Catania, Dept Gen Surg & Med Surg Specialties, Catania, Italy
[6] Univ Cattolica Sacro Cuore, Dipartimento Chirurg Gen, Fdn Policlin Univ A Gemelli, IRCCS, Rome, Italy
关键词
HIPEC; CO2; Ovarian cancer; Colorectal cancer; Gastric cancer; New technology; STAGE ENDOMETRIAL CANCER; QUALITY-OF-LIFE; RECURRENT OVARIAN-CANCER; CLITORAL BLOOD-FLOW; TELELAP ALF-X; CYTOREDUCTIVE SURGERY; FERTILITY PRESERVATION; HYSTEROSCOPIC SURGERY; HIGH-RISK; CARCINOMATOSIS;
D O I
10.1007/s13304-018-0578-5
中图分类号
R61 [外科手术学];
学科分类号
摘要
The most frequent peritoneal surface malignancies originate principally by gastric cancer, colorectal cancer and ovarian cancer. Apart from the origin, peritoneal carcinosis (PC) is considered a negative prognostic factor. The hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal malignancies is considered an attractive method to deliver chemotherapy with enhanced effect directly at the tumor site. The use of such loco-regional approach has proved to improve prognosis of peritoneal carcinomatosis from different origins. Recently, new devices are suitable for loco-regional intraperitoneal chemotherapy as Peritoneal Recirculation System (PRS-1.0 Combat) with CO2 technology. This is a retrospective study with the aim to assess the perioperative outcomes using PRS. Seventeen patients were enrolled affected by colorectal or ovarian cancer. Complete cytoreduction (RT = 0) was achieved for all cases. Median operative time was 420 min (range: 335-665) and median drugs dose used for HIPEC was 137 mg/m2 (115-756). Median EBL was 200 ml (range 50-1000). Median post-operative hospital stay was 9 days (range: 4-24). Treatment-related early complications were recorded in 8 (47.0%) cases and were G1-G2 Major complications occurred in two (11.7%) cases. Considering our aim to test the PRS in different cases and in different pathologies, the results confirmed that the technique is feasible with good perioperative outcomes.
引用
收藏
页码:555 / 560
页数:6
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