The Effect of Calcium Dobesilate on Liver Damage in Experimental Obstructive Jaundice

被引：20

作者：

Unal, Yilmaz ^{[1
]}

Tuncal, Salih ^{[1
]}

Kosmaz, Koray ^{[1
]}

Kucuk, Berkay ^{[1
]}

Kismet, Kemal ^{[1
]}

Cavusoglu, Turgut ^{[1
]}

Celepli, Pinar ^{[2
]}

Senes, Mehmet ^{[3
]}

Yildiz, Selin ^{[3
]}

Hucumenoglu, Sema ^{[2
]}

机构：

[1] Ankara Educ & Res Hosp, Dept Gen Surg, Ankara, Turkey

[2] Ankara Educ & Res Hosp, Dept Pathol, Ankara, Turkey

[3] Ankara Educ & Res Hosp, Dept Biochem, Ankara, Turkey

来源：

JOURNAL OF INVESTIGATIVE SURGERY | 2019年 / 32卷 / 03期

关键词：

calcium dobesilate; hepatobiliary diseases; histopathology; liver; obstructive jaundice; oxidative stress; OXIDATIVE STRESS; N-ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; GLUTAMINE; ACID;

D O I：

10.1080/08941939.2018.1451936

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Purpose/Aim of the study: Inflammation and oxidative stress are two significant factors affecting the degree of liver damage in obstructive jaundice. The aim of this study was to evaluate the effect of calcium dobesilate (CaDob), an effective antioxidant and anti-inflammatory drug, on damage to liver caused by experimental obstructive jaundice. Materials and Methods: 30 rats in total were randomly placed into three groups, each group consisting of 10 rats. The sham group (Group 1) only received solely laparotomy. In the control group (Group 2), ligation was applied to the biliary tract and no treatment was implemented. In the CaDob group (Group 3), following ligation of the biliary tract, 100 mg/kg/day CaDob was implemented via an orogastric tube for a 10-day period. Liver tissue and blood samples were taken for histopathological and biochemical examination. Results: The CaDob group had significantly lower test values for serum liver functions when compared to the control group. Statistically lower levels of tissue malondialdehyde (MDA) and fluorescent oxidation products (FOP) were detected in the CaDob group, and the CaDob group had significantly higher levels of sulfydryl (SH) than the control group. Histopathological scores in the CaDob group were found out to be statistically less than the scores the control group received (p < 0.05). Conclusions: CaDob treatment repaired the histpatological changes induced by bile duct ligation. The hepatoprotective effects of CaDob can be associated with its antioxidant properties of the drug.

引用

页码：238 / 244

页数：7

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