An ingestible bacterial-electronic system to monitor gastrointestinal health

被引：401

作者：

Mimee, Mark ^{[1
,2
]}

Nadeau, Phillip ^{[3
,11
]}

Hayward, Alison ^{[4
,5
]}

Carim, Sean ^{[2
]}

Flanagan, Sarah ^{[3
]}

Jerger, Logan ^{[2
,6
,7
]}

Collins, Joy

McDonnell, Shane ^{[5
]}

Swartwout, Richard ^{[3
]}

Citorik, Robert J. ^{[1
,2
]}

Bulovic, Vladimir

Langer, Robert ^{[5
,8
]}

Traverso, Giovanni ^{[5
,8
,9
]}

Chandrakasan, Anantha P. ^{[3
]}

Lu, Timothy K. ^{[2
,3
,10
]}

机构：

[1] MIT, Microbiol Program, Cambridge, MA 02139 USA

[2] MIT, Synthet Biol Ctr, Cambridge, MA 02139 USA

[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[4] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[5] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[6] MassGen Hosp Children, Div Pediat Gastroentrol Hepatol & Nutr, Dept Pediat, Boston, MA 02114 USA

[7] Harvard Med Sch, Boston, MA 02115 USA

[8] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[9] Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA

[10] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[11] Analog Devices Inc, Boston, MA 02110 USA

来源：

SCIENCE | 2018年 / 360卷 / 6391期

关键词：

LAB-ON-CHIP; MAMMALIAN GUT; DIAGNOSTICS; EVOLUTION; SENSORS;

D O I：

10.1126/science.aas9315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.

引用

页码：915 / 918

页数：5

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