Effect of tomato intake on striatal monoamine level in a mouse model of experimental Parkinson's disease

被引：1

作者：

Suganuma, H ^{[1
]}

Hirano, T ^{[1
]}

Arimoto, Y ^{[1
]}

Inakuma, T ^{[1
]}

机构：

[1] Kagome Co Ltd, Res Inst, Nishinasuno, Tochigi 3292762, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2002年 / 48卷 / 03期

关键词：

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinson's disease; tomato; dopamine;

D O I：

暂无

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

An ingestion of tomato powder rich in lycopene was examined for its effect on mice with Parkinson's disease-like syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To assess the preventive effect of tomato against the MPTP-induced selective destruction of dopaminergic nigrostrie, we determined striatal dopamine (DA). A 4-wk ingestion of the experimental diet containing 20% (w/w) lyophilized tomato powders before MPTP treatment prevented a decrease in the DA level. This suggests that the tomato ingestion might serve as a preventive against neurodegenerative diseases such as Parkinson's disease caused by MPTP and other environmental toxins.

引用

页码：251 / 254

页数：4

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