The involvement of nitric oxide (NO) in the CGRP-induced behavior of rats

被引：4
|
作者：
Kovacs, A
Telegdy, G
Toth, G
Penke, B
机构：
[1] ALBERT SZENT GYORGYI MED UNIV,DEPT PATHOPHYSIOL,H-6701 SZEGED,HUNGARY
[2] ALBERT SZENT GYORGYI MED UNIV,DEPT MED CHEM,H-6701 SZEGED,HUNGARY
来源：
PEPTIDES | 1996年 / 17卷 / 07期
基金：
匈牙利科学研究基金会;
关键词：
CORP; NO; passive and active avoidance behavior; locomotor and grooming activity; transmitters;
D O I：
10.1016/S0196-9781(96)00181-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The possible role cf nitric oxide (NO) in CORP-induced passive avoidance, active avoidance, and open field behavior was tested in rats. A specific NO synthase inhibitor, N-omega-nitro-L-arginine (L-NA), was used to disrupt NO synthesis. ICV administration of 5 mu g of L-NA reversed the action of CORP in passive and active avoidance tests. In an open field, L-NA prevented the action of CORP on locomotion and grooming. The inactive isomer D-NA had no effect on behavior of animals. The data suggest that NO might contribute to CGRP-induced behavior in rats. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码：1183 / 1187
页数：5
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