Are quantitative attenuation measurements of blood by optical coherence tomography feasible?

被引：43

作者：

Faber, Dirk J. ^{[1
]}

van Leeuwen, Ton G. ^{[2
]}

机构：

[1] Univ Amsterdam, Dept Ophthalmol, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands

[2] Univ Twente, Biomed Technol Inst, NL-7500 AE Enschede, Netherlands

来源：

OPTICS LETTERS | 2009年 / 34卷 / 09期

关键词：

OXYGEN-SATURATION; SCATTERING MEDIA; ABSORPTION;

D O I：

10.1364/OL.34.001435

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed. (C) 2009 Optical Society of America

引用

页码：1435 / 1437

页数：3

共 15 条

[1] Confidence intervals on fit parameters derived from optical reflectance spectroscopy measurements [J].

Amelink, Arjen ;

Robinson, Dominic J. ;

Sterenborg, Henricus J. C. M. .

JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (05)

[2] Toward assessment of blood oxygen saturation by spectroscopic optical coherence tomography [J].

Faber, DJ ;

Mik, EG ;

Aalders, MCG ;

van Leeuwen, TG .

OPTICS LETTERS, 2005, 30 (09) :1015-1017

[3] Oxygen saturation-dependent absorption and scattering of blood [J].

Faber, DJ ;

Aalders, MCG ;

Mik, EG ;

Hooper, BA ;

van Gemert, MJC ;

van Leeuwen, TG .

PHYSICAL REVIEW LETTERS, 2004, 93 (02) :028102-1

[4] Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography [J].

Faber, DJ ;

van der Meer, FJ ;

Aalders, MCG ;

van Leeuwen, TG .

OPTICS EXPRESS, 2004, 12 (19) :4353-4365

[5] Light absorption of (oxy-)hemoglobin assessed by spectroscopic optical coherence tomography [J].

Faber, DJ ;

Mik, EG ;

Aalders, MCG ;

van Leeuwen, TG .

OPTICS LETTERS, 2003, 28 (16) :1436-1438

[6] Determination of optical properties of human blood in the spectral range 250 to 1100 nm using Monte Carlo simulations with hematocrit-dependent effective scattering phase function [J].

Friebel, Moritz ;

Roggan, Andre ;

Mueller, Gerhard ;

Meinke, Martina .

JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (03)

[7] Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography [J].

Kagemann, Larry ;

Wollstein, Gadi ;

Wojtkowski, Maciej ;

Ishikawa, Hiroshi ;

Townsend, Kelly A. ;

Gabriele, Michelle L. ;

Srinivasan, Vivek J. ;

Fujimoto, James G. ;

Schuman, Joel S. .

JOURNAL OF BIOMEDICAL OPTICS, 2007, 12 (04)

[8] Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography [J].

Leitgeb, R ;

Wojtkowski, M ;

Kowalczyk, A ;

Hitzenberger, CK ;

Sticker, M ;

Fercher, AF .

OPTICS LETTERS, 2000, 25 (11) :820-822

[9] Determination of optical scattering properties of highly-scattering media in optical coherence tomography images [J].

Levitz, D ;

Thrane, L ;

Frosz, MH ;

Andersen, PE ;

Andersen, CB ;

Valanciunaite, J ;

Swartling, J ;

Andersson-Engels, S ;

Hansen, PR .

OPTICS EXPRESS, 2004, 12 (02) :249-259

[10] Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography [J].

Lu, Chih-Wei ;

Lee, Cheng-Kuang ;

Tsai, Meng-Tsan ;

Wang, Yih-Ming ;

Yang, C. C. .

OPTICS LETTERS, 2008, 33 (05) :416-418

← 1 2 →