New horizon of mucosal immunity and vaccines

被引：47

作者：

Takahashi, Ichiro ^{[1
,2
]}

Nochi, Tomonori ^{[1
]}

Yuki, Yoshikazu ^{[1
]}

Kiyono, Hiroshi ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo 1088639, Japan

[2] Hiroshima Univ, Grad Sch Biomed Sci, Dept Mucosal Immunol, Hiroshima 7348553, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 03期

关键词：

ORAL CHOLERA VACCINE; PATCH DENDRITIC CELLS; T-CELLS; B-CELLS; CVD; 103-HGR; EFFICACY; RESPONSES; TOXIN; TRIAL; IMMUNIZATION;

D O I：

10.1016/j.coi.2009.04.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Progress in the past quarter-century on understanding the molecular, cellular, and in vivo components of the mucosal immune system have allowed us to develop a practical strategy for a novel mucosal vaccine. The mucosal immune system can induce secretory IgA (SIgA) and serum IgG responses to provide two layers of defense against mucosal pathogens. For SIgA-mediated immunity in the gastrointestinal tract, the gut-associated lymphoid tissue contains both the tissue-dependent and tissue-independent IgA components. Harnessing the mucosal immune system for vaccine development may help prevent the global health problems caused by enteric infectious diseases. We have therefore combined mucosal immunology and plant biology to create a rice-based mucosal vaccine that requires neither needles and syringes nor refrigeration.

引用

页码：352 / 358

页数：7

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