Cervical Lymph Node Metastasis Model of Pyriform Sinus Carcinoma

被引：11
|
作者：
Shen, Na [2 ]
Wu, Haitao [1 ]
Xu, Xiuyin [1 ]
Wang, Jianzhong [2 ]
Hoffman, Matthew R. [3 ,4 ]
Rieves, Adam L. [3 ,4 ]
Zhou, Liang [1 ]
机构：
[1] Fudan Univ, Dept Otolaryngol, Eye Ear Nose & Throat Hosp, Shanghai 200031, Peoples R China
[2] Fudan Univ, Dept Otolaryngol, ZhongShan Hosp, Shanghai 200031, Peoples R China
[3] Univ Wisconsin, Dept Surg, Div Otolaryngol Head & Neck Surg, Madison, WI USA
[4] Madison Sch Med & Publ Hlth, Madison, WI USA
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 2009年 / 71卷 / 03期
关键词：
Pyriform sinus carcinoma; VX2; tumor; Cervical lymph node metastasis model; AURICULAR VX2 CARCINOMA; HYPOPHARYNGEAL CANCER; ANIMAL-MODEL; LARYNGEAL; NECK; TONGUE;
D O I：
10.1159/000209313
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objective: To establish a cervical lymph node metastasis model of pyriform sinus VX2 carcinoma and investigate its metastatic features. Methods: VX2 tumor tissue suspension was transplanted into the pyriform sinus submucosa of 15 rabbits under direct laryngoscopy. Rabbits were randomly placed into 1 of 3 groups, each comprised of 5 rabbits. Health evaluation and histopathological analysis were performed on days 14 (group 1), 21 (group 2), and 28 (group 3) after transplantation. Results: VX2 tumors were transplanted successfully in all rabbits. Dysphagia, weight loss, , and dyspnea were observed 28 days after transplantation. Deep cervical lymph node metastasis occurred in all rabbits at all time points. The rate of submandibular lymph node metastasis was 60% in group 1, 80% in group 2, and 100% in group 3. The rate of paratracheal lymph node metastasis was 0% in group 1, 80% in group 2, and 100% in group 3. Conclusions: A model of metastatic pyriform sinus carcinoma was established. This model could be used in future studies evaluating diagnostic and treatment methods. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：129 / 134
页数：6
相关论文
共 50 条
  • [1] Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma
    Chung, Eun-Jae
    Lee, Sang-Hyo
    Baek, So-Hye
    Park, Il-Seok
    Cho, Sung-Jin
    Rho, Young-Soo
    LARYNGOSCOPE, 2014, 124 (04): : 882 - 887
  • [2] Contralateral cervical lymph node metastases in pyriform sinus carcinoma
    Aluffi, P
    Pisani, P
    Policarpo, M
    Pia, F
    OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2006, 134 (04) : 650 - 653
  • [3] LYMPH MODES METASTASIS OF PYRIFORM SINUS CARCINOMA
    BONNAT, H
    CONRAUX, C
    JUNG, GM
    DEBRY, C
    JOURNAL FRANCAIS D OTO-RHINO-LARYNGOLOGIE, 1987, 36 (07): : 319 - 326
  • [4] Cervical node metastasis in Carcinoma of Pyriform Sinus: A prospective analysis of prevalence and distribution
    Sudhindra Saxena
    Nishi Sonkhya
    Prakash Mishra
    Ramesh Yadav
    A. S. Bapna
    Indian Journal of Otolaryngology and Head and Neck Surgery, 2001, 53 (4): : 273 - 276
  • [5] Pattern of cervical lymph node metastasis in medial wall pyriform sinus carcinoma: When do contralateral and paratracheal node dissection necessary?
    Chung, Eun-Jae
    Lee, Dong-Jin
    Park, Il-Seok
    Kwon, Kee-Hwan
    Rho, Young-Soo
    ORAL ONCOLOGY, 2013, 49 : S56 - S56
  • [6] A clinical study on the cervical lymph node metastasis of maxillary sinus carcinoma
    Yagi, K
    Fukuda, S
    Furuta, Y
    Oridate, N
    Homma, A
    Nagahashi, T
    Inuyama, Y
    AURIS NASUS LARYNX, 2001, 28 : S77 - S81
  • [7] Lymph node metastasis in maxillary sinus carcinoma
    Le, QT
    Fu, KK
    Kaplan, MJ
    Terris, DJ
    Fee, WE
    Goffinet, DR
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2000, 46 (03): : 541 - 549
  • [8] Leiomyosarcoma of the maxillary sinus with cervical lymph node metastasis
    Sumida, T
    Hamakawa, H
    Otsuka, K
    Tanioka, H
    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2001, 59 (05) : 568 - 571
  • [9] Prediction Model of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma
    Chen, Huiting
    Zhu, Li
    Zhuang, Yong
    Ye, Xiaojian
    Chen, Fang
    Zeng, Jinshu
    CANCER CONTROL, 2024, 31
  • [10] Indirect computed tomography lymphography identifies lymph node metastasis in rabbit pyriform sinus VX2 carcinoma
    Shen, Na
    Xu, Xiuyin
    Sha, Yan
    Wu, Haitao
    ONCOLOGY LETTERS, 2015, 9 (04) : 1802 - 1806
12345