Cross-Coupling Hydrogen Evolution by Visible Light Photocatalysis Toward C(sp2)-P Formation: Metal-Free C-H Functionalization of Thiazole Derivatives with Diarylphosphine Oxides

被引：150

作者：

Luo, Kai ^{[1
,2
,3
]}

Chen, Yao-Zhong ^{[1
,2
,3
]}

Yang, Wen-Chao ^{[1
,2
]}

Zhu, Jie ^{[1
,2
]}

Wu, Lei ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Coll Sci, Jiangsu Key Lab Pesticide Sci, Nanjing 210095, Jiangsu, Peoples R China

[2] Nanjing Agr Univ, Coll Sci, Dept Chem, Nanjing 210095, Jiangsu, Peoples R China

[3] Nanjing Agr Univ, Coll Plant Protect, Nanjing 210095, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED PHOSPHONATION; P BOND FORMATION; PHOTOREDOX CATALYSIS; STEREOSELECTIVE-SYNTHESIS; ROOM-TEMPERATURE; ARYL MESYLATES; ARYLATION; PHOSPHORYLATION; EFFICIENT; ACIDS;

D O I：

10.1021/acs.orglett.5b03497

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Visible light along with 5 mol % eosin B catalyzed the first direct C-H phosphorylation of thiazole derivatives with diarylphosphine oxides by a photoredox process in the absence of an external oxidant. The scope of thiazoles and phosphine oxides was further investigated, as was functional group tolerance. The general and operational simplicity provides a novel metal and oxidant-free alternative for the formation of heteroaryl-P bonds, and only molecular hydrogen is generated as a byproduct.

引用

页码：452 / 455

页数：4

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