Practical Synthesis of Chromeno[ 2,3-b] indole Skeleton via an Aldehyde Group Insertion/Aromatization Strategy

被引：13

作者：

Liu, Jianming ^{[1
]}

Liu, Na ^{[1
]}

Yue, Yuanyuan ^{[1
]}

Wang, Yanyan ^{[1
]}

Chen, Kaige ^{[1
]}

Zhang, Jia ^{[1
]}

Zhao, Shufang ^{[1
]}

Zhuo, Kelei ^{[1
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henan Key Lab Boron Chem & Adv Energy Mat,Minist, Key Lab Green Chem Media & React,Sch Chem & Chem, Xinxiang 453007, Henan, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 04期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

aldehydes; cyclization; heterocycles; indoles; palladium; C-O BOND; ULLMANN-TYPE SYNTHESIS; ARYL HALIDES; DIARYL ETHERS; ONE-POT; CROSS-COUPLINGS; CATALYZED ARYLATION; PHENOLS; EFFICIENT; SALICYLALDEHYDES;

D O I：

10.1002/asia.201601681

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of chromeno[2,3-b] indole from simple starting materials remains a demanding process. Herein, 2-bromoindole undergoes nucleophilic attack from salicylaldehyde, followed by intramolecular insertion of an aldehyde group and aromatization to generate the desired chromeno[2,3-b] indoles. Moreover, various functional groups were tolerated and a gram-scale synthesis of the product could be achieved under the optimized condition.

引用

页码：401 / 404

页数：4

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