Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency

被引:68
作者
Yan, Long [1 ,2 ,3 ]
Wu, Yixuan [4 ]
Li, Li [4 ]
Wu, Jun [1 ,3 ,5 ]
Zhao, Feiyan [6 ]
Gao, Zheng [4 ]
Liu, Wenjing [3 ,5 ]
Li, Tianda [1 ,2 ,3 ]
Fan, Yong [4 ]
Hao, Jie [1 ,3 ,5 ]
Liu, Jianqiao [4 ]
Wang, Hongmei [1 ,2 ,3 ]
机构
[1] Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Chinese Acad Sci, Dept Stem Cell & Regenerat, Beijing, Peoples R China
[4] Guangzhou Med Univ, Dept Gynecol & Obstet, Key Lab Major Obstetr Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou 510150, Peoples R China
[5] Chinese Acad Sci, Natl Stem Cell Resource Ctr, Beijing, Peoples R China
[6] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Human Reprod Med, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
antral follicle; dominant follicle; follow‐ up; mature follicle; premature ovarian insufficiency; stem cell therapy; umbilical cord mesenchymal stem cell; HORMONE REPLACEMENT THERAPY; IN-VITRO ACTIVATION; BREAST-CANCER; YOUNG-WOMEN; FERTILITY PRESERVATION; ENDOMETRIAL CANCER; NATURAL MENOPAUSE; CONTROLLED-TRIAL; HEART-DISEASE; RAT MODEL;
D O I
10.1111/cpr.12938
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective Premature ovarian insufficiency (POI) is a refractory disease that seriously affects female fertility. Growing body of evidence has indicated mesenchymal stem cells (MSCs) as promising resources in regenerative medicine. In this study, we treated POI patients with umbilical cord-derived MSCs (UCMSCs) and then investigated the restoration of ovarian function and clinical outcomes through follow-ups. Materials and methods Sixty-one patients diagnosed with POI participated in this study. UCMSCs were isolated and cultured according to GMP standards, and then transplanted to the patients' ovary by orthotopic injection under the guidance of vaginal ultrasound. We monitored side effects, vital signs and changes in clinical and collected haematological and imaging parameters during the follow-ups. Results All patients showed normal clinical behaviour without serious side effects or complications relevant to the treatment. Transplantation of UCMSCs rescued the ovarian function of POI patients, as indicated by increased follicular development and improved egg collection. POI patients who experienced shorter amenorrhoea durations (<1 year) seemed to obtain mature follicles more easily after stem cell therapy, and patients with better ovarian conditions (pre-operative antral follicles) were more likely to derive the better outcomes by UCMSC injection. Four successful clinical deliveries were obtained from POI patients after UCMSC transplantation, and all of these babies are developed normally. Conclusions The clinical trial result sugggests a possible therapy for POI by UCMSC transplantation.
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页数:12
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